糖肾灵治疗糖尿病肾病30例临床观察

Clinical Observation of Treating 30 Cases of Diabetic Nephropathy with Tangshenling

目的:寻求延缓糖尿病肾病肾功能恶化的中西医结合治疗的有效方法。方法:将60例病例随机分为两组。两组性别、年龄、24小时尿蛋白定量和血肌酐经统计学处理差异无显著性意义。经饮食、运动及降糖药物治疗,有效严格地控制血糖,使空腹血糖<7.0mmol/L,糖基化血红蛋白<8%。对照组用洛汀新治疗,治疗组用糖肾灵+洛汀新治疗,疗程2个月,检测治疗前后24小时尿蛋白定量、Scr及BUN水平。结果:两组治疗前后Scr水平差异均无显著性意义,P>0.05;两组治疗后尿蛋白定量下降,与治疗前比较,P均<0.05。治疗组降低尿蛋白的疗效又明显优于对照组,P<0.05。结论:中西医结合治疗在延缓糖尿病肾病肾功能恶化、改善患者生活质量方面优于单用西药治疗。

Objective：To explore the effective therapeutic method of traditional Chinese medicine combined with western medicine to postpone renal function deterioration of diabetic nephropathy. Methods：60 eases of diabetic nephropathy were randomly divided into the treatment group and the contrast group. Two groups had no significant difference by statistics in age, sex, urine protein/24h and serum createnine. By control of die, sport and hypoglycemic drug, blood glucose was strictly controlled with fasting plasms glucose （FPG） 〈 7.0mmol/L and glycolsylated hemoglobin 〈 8%. The contrast group was treated by Lotensin and the treatment group by Tangshenlin and Lotension for two months. Urine protein/24h, serum creatinine （Scr） and blood uria nitrogen （BUN） was detected before and after treatment. Results ：The level of Scr in two groups had no significant difference （ P 〉 0.05 ） and the decrease of BUN in two groups had statistical meaning （ P 〈 0.05 ）. The decrease of BUN in the treatment group was much than that in the contrast group （ P 〈 0.05 ）. The parameter of hemorheology and trauma of nerve function were obviously improved （P 〈 0.01 ）. Conclusion： Treating with traditional Chinese medicine combined with western medicine has better effect than only western medicine in postponing renal function deterioration of diabetic nephropathy and improving life quantity.