代谢综合征与颈动脉粥样硬化关系的临床研究

The clinical study of the association between metabolic syndrome and carotid atherosclerosis

目的研究代谢综合征(MS)与颈动脉粥样硬化的关系,并探讨其临床意义。方法按照国际糖尿病联盟(IDF)MS全球共识定义的诊断标准,选择56例MS患者,并同期选择非代谢综合征48例作对照,对受试者行颈动脉彩色多普勒超声检查。结果MS患者颈动脉内膜-中膜厚度(IMT)值((1.09±0.31)mm)、斑块指数(1.13±0.85)、斑块总积分(1.71±1.82)及斑块的发生率(67.4%)均显著高于对照组(分别为(0.72±0.22)mm,0.28±0.53,0.41±0.79,16.9%)(P均<0.05)。结论MS易导致动脉粥样硬化,对MS患者常规行颈动脉超声检测,有助于早期预测和防治冠心病及其他动脉粥样硬化性疾病。

Objective It is to study the association between metabolic syndrome（MS） and carotid atherosclerosis, and to evaluate its clinical significance. Methods 56 MS patients were enrolled according to MS diagnostic standard of the new worldwide definition commented by International Diabetes Federation（IDF） （MS group）. 48 non-MS subjects served as a control （non-MS group）. Carotid arteries of all subjects of two groups were detected by color Doppler ultrasound. Results The carotid artery intima-media thickness（IMT） （ （ 1.09±0.31 ） ram）, plaque index（ 1.13 ± 0.85 ）, plaque total scores （ 1.71±1.82） and plaque occurrence rate （67.4 % ） of MS group were much higher than those of the control group（ （0.72±0.22） ram,0.28± 0.53,0.41 ± 0.79 and 16.9 % ） （ P〈0.05 ）. Conclusions MS may induces and accelerates the course of atherosclerosis. Routinely detecting carotid artery of MS cases by ultrasound is beneficial to predict and control coronary and other artery disease much earlier.