摘要主要对Ghrelin的历史背景、结构与功能、受体的分布、生物学的作用及其前景展望作出详细的论述。The history, structure and function, receptor＇ distribution, biological action, and prospect of Ghrelin was reviewed.
1[1]Kojima M,Hosoda H,Date Y,et al,Ghrelin is a growthhormone-releasing acylated peptide from stomach[J].Nature 1999,402:656-660.
2[2]Tsehop M,Smiley N,Date Y,et al.ghrelin in induces adiposity in rodents[J].Nature 2000,407:194-198.
3[3]Nakazato M,Muralami N,Date Y,et al.A role for ghrelin in the central regulation of feeding[J].Nature,2001,409:194-198.
4[4]Howard AD,Feighner SD,Cully DF,et al.A receptor in pituirary and hypothalamus that function in growth hormone release[J].Science 1996,273(5277):974-977.
5[5]Date Y,Kojima M,Hosoda H,et al.Ghrelin,a novel growth-hormone-release acylated peptide,is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.Endocrinology,2000,141:4255-61.
6[6]Hosoda H,Kojima M,Matsuo H,et al.Ghrenlin and desacyl ghrenlin:two major forms of rat ghrenlin peptide in gastrointestinal tissue.Biochem Biophys Res Commun,2000,279:909-913.
7[7]Tolle V V,Zizzari P,Tomasetto C,et al.In vivo effets of ghrenlin/motilin-related peptide on growth hormone secretion in the rat[J].Neuroendocrinology,2001,73:54-61.
8[8]Dieguez C,Casanueza F F.Ghrelin:a step forward in the understanding of somatotroph cell fuction and growth regulation[J].Eur J Endo-crinol,2000,142:413-417.
9[9]Korbonits M,Bustin SA,Kojima M,et al.The expression of the growth hormone secretagogue receptor ligand in normal and abnormal human pituitary and other ne-uroendocrine tumors[J].Clin endocrinol Metab,2001,86:881-887.
10[10]Mori K,Yoshimoto A,Takaya K,et al.kidney produces a novel acylated peptide,ghrelin expression.FEBS Lett 2000,486:213-216.
