血清尿酸、胆红素与冠心病关系的临床探讨

Clinical Discussion of the Relationship between the Levels of Serum Uric Acid,Bilirubin and Coronary Heart Disease

目的:探讨血尿酸、胆红素与冠心病发生、发展的关系。方法:随机抽取59例冠心病患者和52例健康者进行血尿酸、胆红素水平检测与对比分析。结果:冠心病组病人血尿酸水平明显升高(P<0.01),总胆红素、间接胆红素显著降低(P<0.05),且与冠脉病变程度相关;但直接胆红素水平无明显差异(P>0.05)。结论:血尿酸水平升高和胆红素水平降低与冠心病密切相关,早期干预有可能预防心血管事件的发生。

Objective.. To investigate the relationship between the levels of serum uric acid, bilirubin and the occurrence of coronary heart disease（CHD）. Methods： 59 cases of CHD patients and 52 cases of healthy controls were ran domly chosen for observation and comparison of the levels of serum uric acid and bilirubiru Results. The levels of serum uric acid increased more significantly in CHD group than that in control group（P〈0. 01）, but total and direct bilirubin concentrations reduced in CHD group more markedly than that in control group（P〈0. 05）, These are related with the crown arteries pathological change degree. There was little difference in indirect bilirubin of two groups （P〉 0. 05）. Conclusion： The increase of serum uric acid concentrations and the reduce of bilirubin concentrations are related to CHD. It is possible to prevent the cardiovascular event by way of early intervention.