培哚普利对心房颤动复律并维持窦性心律的临床疗效

Clinical Efficacy of Perindopril on the Maintenance of Sinus Rhythm after Atrial Fibrillation Cardioversion

目的:评价胺碘酮联合应用培哚普利对心房颤动复律后维持窦性心律的临床疗效。方法:新发心房颤动患者成功转复窦性心律后共97例,随机分为2组:胺碘酮组(Ⅰ组)47例和胺碘酮联用培哚普利组(Ⅱ组)50例,随访18个月,观察两组患者治疗后维持窦性心律情况及左心房内径。结果:两组患者治疗后,前6个月两组间窦性心律维持率无显著差异(P>0.05),而治疗9个月后,Ⅱ组患者窦性心律维持率明显高于Ⅰ组患者,两组间有显著统计学差异(P<0.05)。左心房内径在治疗6个月时,两组间无显著差异(P>0.05),治疗12个月后,左心房内径两组间有显著差异(P<0.05)。结论:胺碘酮联合应用培哚普利对心房颤动复律后窦性心律的维持有良好的临床疗效,并能延缓左心房的扩大。

Objective： To assess clinical efficacy of amiodarone combined with perindopril in maintaining the sinus rhythm after cardioversion of persistent atrial fibrillation. Methods. 97 cases of recency atrial fibrillation who had been successfully converted to sinus rhythm were randomly assigned into group Ⅰ （47 cases, in which patients were treated with amiodarone） and group Ⅱ （50 cases, in which patients were treated with amiodarone plus perindopril）. The therapeufic effects of all these cases on maintenance rates of sinus rhythm and the left atrial diameter（LAD） were followedup for 18 months. Results： The maintenance rate of sinus rhythm in group Ⅰ was lower, but not significant than that in group Ⅱ before the 6th month（P〉0. 05）, however, the maintenance rate of sinus rhythm in the group Ⅱ were significantly higher than that in group Ⅰ （P〈0. 05）. The difference of LAD was not significant between the two groups before and at the 6th month after treatment. At the 12th month after treatment, LAD in group T was significantly enlarged compared with that in group Ⅱ （P〈0. 05）. Conclusion： The combination of perindopril and amiodarone is more effective for sinus rhythm maintenance, may delay the enlargement of LAD.