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阿昔洛韦片含量测定结果的不确定度评定 被引量:1

Evaluation of uncertainty measurement in the content determination of aciclovir tablets by UV
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摘要 目的:建立阿昔洛韦片含量测定结果的不确定度评定。方法:分析了阿昔洛韦片含量测定过程中样品含量重复性测量、样品的称样量、样品的稀释体积和紫外分光光度法的测量等因素对阿昔洛韦片含量测定不确定度的影响。结果:扩展不确定度 U_(95)为0.8%,覆盖因子 k=2。结论:本法可靠。 Objective: To establish a method for the evaluation of the uncertainty of the content determination of aciclovir in aciclovir tablets by UV. Method:The sources of the uncertainty in the content determination of aciclovir tablets were analyzed. The influencing factors on the uncertainty in the procedure of the content determination were evaluated, including repeatability of results of measurements, the weight of sample, the dilated volume of sample, the measurement by ultraviolet visible absorption spectroscopy. Results: The expanded uncertainty U95 was 0.8%, the coverage factor was 2. Conclusion:The evaluation is reliable.
作者 张平 梁春卿
出处 《药物分析杂志》 CAS CSCD 北大核心 2007年第1期141-144,共4页 Chinese Journal of Pharmaceutical Analysis
关键词 测定不确定度 含量测定 紫外分光光度法 阿昔洛韦片 评定 uncertainty of measurement content determination UV aciclovir tablets evaluation
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  • 1General Requirements for the Competence of Testing and Calibration Laboratories(检测和校准实验室能力的通用要求).ISO,Geneva,2005.10
  • 2Drug Specifications Promulgated by the Ministry of Public Health,PR China.Vol3[卫生部药品标准(新药转正标准)第三册].1994.53
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  • 4Guide to the Expression of Uncertainty in Measurement(测量不确定度的表述指南).ISO Geneva,1993.1
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