摘要
2C类蛋白磷酸酶(PP2C-type prote in phosphatases,PP2C)是一类丝氨酸/苏氨酸残基蛋白磷酸酶,在细胞内以单体形式存在,酶催化活性依赖于Mg2+或Mn2+。PP2C通过去磷酸化作用负调控蛋白激酶级联信号系统,参与细胞周期、胁迫信号转导、基因转录、蛋白质翻译及翻译后修饰等细胞活动过程。H2O2、不饱和脂肪酸、Ca2+/CaM、脂质信号分子等均可调节PP2C的活性。
The PP2C-type protein phosphatases （PP2C） are a kind of monomeric enzymes that present in both prokaryotes and eukaryotes. They are a distinct family of Ser/Thr protein phosphatases. A distinguishing feature of PP2C is their requirement of Mn^2＋ or Mg^2 ＋ for their activity. PP2C exert their negative regulations to protein kinase cascades by dephosphorylating at the Ser/Thr residue of proteins. PP2C have been found as the regulators of cell cycle, stress-lnduced MAPK pathway, gene transcription, protein translation and post-translation modifications et al. Their activities could be regulated by H2O2, unsaturated fatty acid, Ca^2＋/CaM and endogenous lipid messengers.
出处
《南京农业大学学报》
CAS
CSCD
北大核心
2007年第1期136-141,共6页
Journal of Nanjing Agricultural University
基金
博士后科学基金(2005037524)
关键词
2C类蛋白磷酸酶
结构
功能
PP2C-type protein phosphatases （PP2C）
structure
function
