溶栓时间与急性心肌梗死血管再通率的临床研究

Clinical Research of Revascularization in Different Time Acute Myocardial Infarction Treated by Thrombolysis

目的:探讨急性心肌梗死(AMI)后不同时间溶栓治疗对血管再通的影响。方法:回顾性分析96例AMI患者的溶栓疗效,根据发病后时间溶栓分为0～3h,>3～6h,>6～12h三组。结果:三组血管再通率分别为86.96%、74.51%、61.91%。早期治疗(0～6h)组血管再通率(78.38%)与延迟治疗(>6～12h)组的61.91%相比较,差异有显著性意义(P<0.05);两组五周病死率、反复心绞痛和反复Ⅱ度以上房室传导阻滞(AVB)相比,差异显著(P<0.01)。结论:AMI发病后6h内溶栓治疗,血管再通效果最好,住院病死率最低,但发病时间>6～12h的溶栓治疗仍可取得较好的效果。

Objective： To investigate the effect of revasculafization in the different time after acute myocardial infarction （AMI） treated by thrombolysis. Methods： The 96 AMI patients were divided into three groups according to thrombolytie time after AMI：0-3 h, 〉 3-6 h, 〉 6-12 h. Results： The reopen rate of blood vessel was 86.96%, 74.51% and 61.91% in the three groups respectively. The difference in the reopen rate of blood vessel between earlier therapy （0-6 h） and delayed therapy （ 〉 6-12 h） was significant （78.38%, 61.91%, P 〈 0.05）, the difference of mortality, repeating angina pectoris, 1I degree atrioventricular block during 5 weeks between these two groups were highly significant （P 〈 0.01）. Conclusion： Thrombolytie therapy in 6 hours after AMI has better effect but delayed therapy （〉 6-12 h） still has moderate effect.