1Comp PC;Esmon CT.Regulatory mechanisms in hemostasis:natural anticoagulants,1991.
2Bernard GR;Margolis BD;Shanies HM.Extended evaluation of recombinant human activated protein C United States trial (ENHANCEUS),a single-arm,phase 3B,multicenter study of drotrecogin alfa in severe sepsis[J],2004(06).
4Yan SB;Helterbrand JD;Hartman DL.Low levels of protein C are associated with poor outcome in severe sepsis[J],2001.
5Bernard GR;Ely EW;Wright TJ.Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis[J],2001(11).
6Janet Liang;Stephen Streat;John Torrance.Drotrecogin alfa (recombinant human activated protein C)in severe sepsis-α New Zealand viewpoint,2003.
7Bernard GR;Macias WL;Joyce DE.Safety assessment of drotrecogin alfa (activated)in the treatment of adult patients with severe sepsis[J],2003(02).
8Bearden DT;Garvin CG.Recombinant human activated protein C for use in severe sepsis[J],2002(09).
9Akio M;Kenji O;Mitsuhiro U.Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation[J],2000(12).
10Cheng T;Liu D;Griffin JH.Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective[J],2003(03).
二级参考文献7
1Amaral A, Opal SM, Vincent JL. Coagulation in sepsis. Intensive Care Med, 2004,30(6): 1032-1040.
2Griffin JH, Zlokovic B, Fernandez JA. Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol,2002,39(3):197-205.
3Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med, 2001,344:699-709.
4Yan SB, Dhainaut JF. Activated protein C versus protein C in severe spsis. Crit Care Med, 2001,29(7 Suppl):69-74.
5Eckle I, Seitz R, Egbring R, et al. Protein C degradation in vitro by neutrophil elastase. Biol Chem Hoppe Seyler, 1991,372:1007-1013.
6William LM, David RN. Severe protein C deficiency predicts early death in severe sepsis. Crit Care Med, 2004,32(5):223-228.
7White B, Schmidt M, Murphy C, et al. Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB(NF-кB)and tumor necrosis factor(TNF-α)production in the THP-1 monocytic cell line. Br J Haematol, 2000,110:130-134.