172例门诊留查患儿药物不良反应报告分析

Analysis of 172 adverse drug reaction reports on under-observation children

目的:调查药物不良反应(ADR)发生情况,促进临床合理用药。方法:对本院门诊留察室上报的172例ADR报告分别从患儿年龄、性别、涉及药物种类及临床表现、联合用药情况等方面进行分析和统计。结果:172例ADR报告中涉及药品36种,β-内酰胺类抗生素占56.98%,抗感染中药占26.74%,临床表现以皮肤过敏反应最多占64.53%。结论:应重视ADR监测工作,促进临床合理用药。

Objective：To study the characteristics of adverse drug reaction（ADR） in our hospital and to promote a rational clinical use of drugs. Methods： 172 ADR cases had been collected from observation room of out-patient department in our hospital. All cases were analyzed in respects of age, sex, drugs administrated, clinical manifestation and drug combination etc. Results： 36 kinds of drugs causing ADR were reported in these 172 cases, with β-lactam antibiotics accounting for 56.98% and anti-infection traditional Chinese medicine accounting for 26.74%. Most were induced by skin anaphylaxis, which accounted for 64.53%. Conclusions： ADR monitor must be strengthened in order to guide the clinically rational use of drugs.