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核转录因子κB与脑缺血再灌注损伤 被引量：8

NF-kappa B and cerebral ischemia reperfusion
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作者 徐静 王兴勇
机构地区 重庆医科大学附属儿童医院
出处 《儿科药学杂志》 CAS 2007年第1期58-61,共4页 Journal of Pediatric Pharmacy
基金 重庆市科学技术委员会科研基金(CSTC 2005BB5228)
关键词 脑缺血再灌注损伤 核转录因子ΚB 细胞内钙超载 CIRI 细胞凋亡 凋亡相关基因 氧化应激 炎症反应
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献24

  • 1Won SJ,Kim DY,Gwag BJ.Cellular and molecular pathways of ischemic neuronal death[J].Biochem Mol Biol,2002,35(1):67-86.
  • 2Lee JK,Burckart GJ.Nuclear factor kappa B:important transcription factor and therapeutic target[J].J Clin Pharmacol,1998,38(11):981-993.
  • 3O'Neill LA,Kahschmidt C.NF-kappa B:a crucial transcription factor for glial and neuronal cell function[J].Trends Neumsci,1997,20:252-258.
  • 4Shen W,Zhang C,Zhang G.Nuclear factor kappa B activation is mediated by NMDA and non-NMDA recepter and L-type voltagegated CA2+ channel follow severe global ischemia in rat hippocampus[J].Brain Res,2002,933(1):23-30.
  • 5Stephenson D,Yin T,Smalstig EB,et al.Transcription factor nuclear factor-kappa B is activated in neurons after focal cerebral ischemia[J].Cereb Blood Flow Metab,2000,20(3):592-603.
  • 6Williams AJ,Hale SL,Moffett JR,et al.Delayed treatment with MLN51 9 reduces infarction and associated neurologic deficit caused by focal ischemic brain injury in rats via antiinflammatory mechanisms involving nuclear factor-kappa B activation,gliosis,and leukocyte infiltration[J].Cereb Blood Flow Metab,2003,23(1):75-87.
  • 7Nurmi A,Lindsberg PJ,Koistinaho M,et al.Nuclear factor-kappa B contributes to infarction after permanent focal ischemia[J].Stroke,2004,35(4):987-991.
  • 8Crack PJ,Taylor JM.Reactive oxygen species and the modulation of stroke[J].Free Radic Biol Med,2005,38(11):1433-1444.
  • 9Clemens JR,Stephenson DT,Yim T,et al.Drug-induced neuroprotection from global ischemia is associated with prevention of persistent but not transient activation of nuclear factor-kappa B in rats[J].Stroke,1998,29(3):677-682.
  • 10Domanska-janik K,Bronisz-Kowalozyk A,Zajac H,et al.Interrelations between nuclear factor-kappa B activation,glialresponse and neuronal apotosis in gerbil hppocampus after ischemia[J].Acta Neurobiol Esp (Warsz),2001,61(1):45.

二级参考文献37

  • 1邱丽颖,余涓,周宇,陈崇宏.阿司匹林对大鼠局灶性脑缺血-再灌注损伤的保护作用及机制[J].药学学报,2003,38(8):561-564. 被引量：28
  • 2Lawrence MS, Mclaughlin JR, Sun GH, et al. Herpes simplex viral vectors expressing Bcl- 2 are neruoprotective when delivered after a stroke[J]. J Cereb Blood Flow Metab,1997~17(7) :740 - 744.
  • 3Antonawich FJ, Federoff HJ, Davis IN. Bcl - 2 transduction, using a herpes simplex vires amplicon, protects hippocampal neurons from transient global ischemia[ J ]. Exp Neurol, 1999,156(1) : 130 - 137.
  • 4Korsmeyer SJ. Bcl2 gene family and the regulation of programmed cell death[J]. Cancer Res, 1999,59(7):1693- 1700.
  • 5Cao GD, Minami M, Pei W, et al. Intraeellular bax translocation after transient cerebral ischemia: implications for a role of the mitochondreal apoptotic signaling pathway in ischemic neuronal death[J]. J Cereb Blood Flow Metab,2001,21(4) :321-333.
  • 6Adams JM,Cory S. The Bcl- 2 protein family:arbiters of cell survival[J]. Science, 1998,281(5381) : 1322 - 1326.
  • 7Yin XM,Oltvai ZN, Korsmeyer SJ. BH1 and BH2 domains of Bcl -2 are required for inhibition of apoptosis and heterodimerization with Bax[J]. Nature, 1994,369(6478) :321 - 323.
  • 8Mohr JP,Orgogozo JM,Harrison MJG,et al.Meta-analysis of oral nimodipine trials in acute ischemic stroke[J].Cerebrovasc Dis,1994,41(6):197—203.
  • 9Dimagl U,ladecola C,Michael A.Pathobiology of ischemic stroke:anintegrated view[J].Trends Neurosci,1999,22(9):391—397.
  • 10Neumar RW.Molecular mechanisms of ischemic neuronal injury[J].Ann Emerg Med,2000,36(5):483—506.

共引文献68

同被引文献137

引证文献8

二级引证文献42

儿科药学杂志
2007年 第1期

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