新城疫病毒主动特异性免疫疗法对乳腺癌患者免疫功能的影响

Effect of the using of newcastle disease virus as active specific immunotherapy in breast cancer

目的观察新城疫病毒主动特异性免疫疗法对乳腺癌患者免疫功能的影响。方法应用流式细胞术,检测乳腺癌患者在接种疫苗前后,其外周血单个核细胞(PBMC)中T细胞亚群CD3+、CD4+、CD8+及NK细胞中的CD16和CD57等免疫学指标变化。结果33例患者在术前及接种疫苗1￣3周后的免疫学指标变化明显,其差异有显著性,P<0.05。结论新城疫病毒主动特异性免疫疗法能显著提高乳腺癌患者的免疫功能,且毒副作用轻微。

[Objective] To study the influence of newcastle disease virus as active specific immunotherapy in breast cancer. [Methods] Using flow cytometry to detect the immunoherapy change of the breast carcinoma patients after the using of newcastle disease virus. [Results] Treated by active specific immunotherapy, the patient＇s CD3^＋, CD4^＋, CD8^＋ and NK cell number were greatly changed （P 〈0.05）. [Conclusion] Newcastle disease virus as active specific immunotherapy can improve effectively the patients＇s immunity with less damage.