复方中药抑制免疫反应的研究

Study of complex prescription Chinese materia medica inhibiting immunological reaction

目的研究复方中药制剂的免疫抑制作用。方法用卵白蛋白和弗氏完全佐剂(OVA+FCA)免疫小鼠制作免疫反应鼠,观察雷公藤组、复方中药组和对照组用药前、用药后小鼠血清IgG水平的变化及脾脏质量和脾脏系数。结果与对照组相比,雷公藤组和复方中药组均能使脾脏质量和脾脏指数I、gG水平下降,但雷公藤组无显著性差异,而复方中药组有显著性差异(P<0.05)。复方中药组与雷公藤组比较也有显著性差异(P<0.05)。结论复方中药能明显抑制小鼠免疫反应,并比单用雷公藤更有效。

Objective It is to study the immunosuppressive action of complex prescription Chinese materia medica preparation, Methods The immunological reaction mice were established with OVA and CFA, Serum IgG level change, spleen mass and spleen coefficient of the mice in Tripterygium wilfordii group, complex prescription Chinese materia medica group and control group before and after medication were observed, Results Compared with control group, spleen mass, spleen coefficient and IgG level lowered in Tripterygium wilfordii group and complex prescription Chinese materia medica group. There was no significant difference between Tripterygium wilfordii group and control group （P 〉0.05）. There was significant difference between complex prescription Chinese materia medica group and control group （P 〈0.05）. There was significant difference between complex prescription Chinese materia medica group and Tripterygium wilfordii group （ P （0,05）. Conclusion Complex prescription Chinese materia medica can obviously inhibit immunological reaction of mice, which is better than Tripterygium wilfordii only.