音乐治疗合并国产利培酮治疗精神分裂症阴性症状对照研究

Comparative Study of the Music Therapy on the Negative Symptoms of Schizophrenia with Native Risperidone

目的探讨音乐治疗合并国产利培酮对精神分裂症阴性症状的改善。方法将60例住院男性慢性分裂症患者随机分为音乐治疗合并国产利培酮组(研究组)和单用国产利培酮组(对照组)各30例。观察时间8周,采用BPRS、SANS和NOSIE量表评定疗效。结果研究组显著进步率(痊愈率+显效率)高于对照组(χ2=4.35,P<0.05);研究组在治疗4周后,BPRS、SANS比治疗前有显著下降(P<0.05),在8周末下降更明显(P<0.01),而对照组在4周评分与疗前差异不显著(P>0.05),在8周末评分下降显著(P<0.05);两组在治疗后4周、8周SANS减分均数均有显著性差异(P<0.01),两组BPRS减分均数均有显著性差异(P<0.01),8周末NOSIE量表减分均数均有显著性差异(P<0.05)。结论音乐治疗合并国产利培酮治疗精神分裂症阴性症状的改善优于单用国产利培酮治疗。

Objective To evaluate the effects of the music therapy on the negative symptoms of schizophrenia with native Risperidone. Methods The sixty male schizophrenia chronic in-patients were divided into two groups randomly; 30 to the music with native Risperidone therapy group, the other 30 to the single native Risperidone therapy group. All these patients were assessed by BPRS, SANS and NOSIE, the duration weeks. Results The improving rate of studying group （including thorough and obvious curing） is higher than that of control group （X^2=4. 35, P〈0. 05） ; The BPRS, SANS of the studying group decreased significantly after 4 weeks＇ treatment （P〈0. 05）. Much more at the end of the 8th week （P〈0. 01）. The BPRS, SANS of the control group had no significant decrease after 4 weeks＇treatment （P〉0. 05）. But significant difference emerged at the end of 8th week （P〈0. 05）. The SANS average descendents of the two groups had most significant difference in the 4th and 8th week （P〈0. 01）. The BPRS average descendents of the two groups had significant difference after the curing （P〈0. 01）. After the 8th week, there were significant difference between two groups on these most factors of the NOSIE＇s （P〈0. 05）. Conclusions Music therapy on the negative symptoms of schizophrenia with native Risperidone is of better efficacy than single Risperidone group .