主客体包结法选择分离白花前胡的化学成分

Selective Isolation of Component of Baihuaqianhu Using Inclusion Crystalline of Host and Guest

以1,1,6,6-四苯基-2,4-己二炔-1,6-二醇为主体分子,可简单、迅速地从白花前胡粗提物中选择分离有效成分3'-乙酰氧基-4'-β-羟基丙酰氧基-3',4'-二氢邪蒿内酯,收率为0.17%.IR,1H NMR,13C NMR光谱和单晶衍射证实了包结化合物的形成及其晶体结构,并且用气相色谱方法(GC)评价了选择分离效果.

3＇-Acetoxy-4＇-β-hydroxyl-propyloxy-3＇,4＇-dihydroseselin can be selectively isolated from the crude of BAIHUAQIANHU simply and rapidly using 1,1,6,6-tetraphenylhexa-2,4-diyne-1,6-diol as host with yield of 0.17%. Inclusion compound crystal structure was confirmed by IR, ^1H NMR, ^13C NMR spectra and single crystal X-ray diffraction analysis, GC method was used to assess the isolation effect.