慢性阻塞性肺疾病患者血清皮质醇水平的动态变化

The dynamic changes of the serum level of cortisone in the patients with chronic obstructive pulmonary disease.

目的 探讨慢性阻塞性肺疾病（COPD）患者血清皮质醇水平的动态变化，为临床治疗提供依据。方法 应用放射免疫法检测50例COPD患者急性加重期与稳定期血清皮质醇水平。选择同期健康对照组30例。结果 COPD急性加重期与稳定期血清皮质醇水平明显低于健康对照组（P〈0．01），而COPD急性加重期血清皮质醇水平亦明显低于稳定期（P〈0．05）。结论 COPD患者不论急性加重期或稳定期，血清皮质醇水平均低下，在常规治疗的前提下，适当的糖皮质激素抗炎治疗可能会延缓COPD的发展。

Objective To study the dynamic changes of the serum level of cortisone in the patient with chronic obstructive pulmonary disease（COPD） in order to guide clinical treatment. Methods The serum levels of cortisone in 50 patients with COPD of acute exacerbation and stationary phase were measured by radioimmunity means. The control group included 30 healthy people. Results The serum levels of cortisone decreased obviously in the COPD patients during acute exacerbation and stationary phase compared with that in the healthy people （ P 〈 0. 01 ）. Meanwhile the serum level of cortisone decreased obviously in COPD patient during acute exacerbation phase compared with that stationary phase （ P 〈 0.05 ）. Conclusion The serum level of cortisone is lower in the patients with COPD of acute exacerbation and stationary phase. The reasonable anti-inflammation treatment with glucorticoid can postpone COPD progress in addition to the routine treatment.