慢性阻塞性肺疾病患者血栓前状态的研究

Prethrombolic state of patients with chronic obstructive pulmonary disease.

目的探讨慢性阻塞性肺疾病（COPD）患者的血液凝血系统功能的改变。方法采集COPD急性加重期患者82例、稳定期患者25例和20例正常对照者的外周静脉血，测定D-二聚体、纤维蛋白原（Fb）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血时间（TT）。结果COPD急性加重期组与稳定期组比较。D-二聚体、Fb、PT、APTT、TT间差异无显著性。较正常对照组比较，D-二聚体和Fb水平升高，差异有显著性。COPD重度患者与轻中度患者间比较，D-二聚体和Fb水平差异有显著性（P〈0．01）。结论COPD急性加重期和稳定期患者，凝血系统加强，抗凝系统减弱，存在血栓前状态。

Objective To study the function changes of coagulation system in patients with chronic obstructive pulmonary disease （ COPD ）. Methods The peripheral vein blood samples were taken from 82 COPD cases at acute worsening period,25 stable cases and 20 normal controls for the determination of D-dimer, Fibrinogen （ Fb ）, Prothrombin time（PT） ,Activated partial thromboplastin time（APTT） and thrombin time（TT）. Results D-dimer,Fb, PT,APTT and Tr were not significantly different between acute worsening COPD patients and stable patients but D- dimer and Fb level were higher in acute worsening COPD patients than normal controls. D-dimer and Fb level were significanfly different between severe COPD patients and slight and mediate COPD patients （ P 〈 0.01 ）. Conclusion Coagulation function is strengthened and anti-coagulation system is weakened in acute worsening and stable COPD patients,in whom prethrombolic state exists.