叶下珠对小鼠酒精性肝损伤的保护作用

Protective effect of phyllanthus urinaria on alcohol-induced liver injury in mice

目的研究叶下珠对小鼠酒精性肝损伤的保护作用。方法将30只小鼠随机分为3组:空白对照组小鼠每日以常规饲料和自来水喂养;酒精损伤组小鼠每日以白酒连续灌胃,常规饲料中拌有白酒;叶下珠保护组小鼠将白酒加浓度70%的叶下珠提取液按酒精损伤组动物灌胃。4周后,处死小鼠,取小鼠血清和肝脏测定ALT、AST、MDA、SOD等指标。结果叶下珠处理能够抑制血清谷草转氨酶(AST)、谷丙转氨酶(ALT)和肝脏的丙二醛(MDA)上升,其AST、ALT和MDA值比酒精损伤组分别下降了52.5%、41.4%和29.3%。同时叶下珠也能提高超氧化物歧化酶(SOD)的活性,处理后SOD值上升了16.3%。结论叶下珠对小鼠酒精性肝损伤有明显的保护作用。

Objective To study the protective effect of phyllanthus urinaria on alcohol-induced liver injury in mice. Methods 30 mice were randomly divided into three groups. Mice in control group were fed with conventional forage and water daily ;in alcohol group were with alcohol consecutively and forage mixed with alcohol; and in phyllanthus urinaria group with alcohol and phyllanthus urinaria extraction. All mice were killed after four weeks and the index of aspartateamino transferase （AST）, alanine aminotransferase （ALT）, malonyldialdehyed （ MDA ）, superoxide dismutase （SOD） were measured. Result Phyllanthus urinaria obviously suppressed the contents of ALT, AST, MDA and increase the activity of SOD enzyme. The numbers of phyllanthus urinaria treatment about ALT,AST and MDA reduced 52. 5% ,41.4% and 29. 3% and the SOD value raised by 16.3%. Conclusion Phyllanthus urinaria has certain protecting action on hepatic injure caused by alcohol in mice.