合用尿囊素铝对司帕沙星片生物利用度的影响

The influence of staggered dosing of aldioxa on oral bioavailability of sparfloxacin

目的:研究合用尿囊素铝片对司帕沙星(SPLX)片生物利用度的影响,寻找合用该二药时最佳给药方案。方法:将志愿者分成A、B、C、D4组,分别以不同给药方案给药。A组作为对照组,口服司帕沙星片400mg;B、C、D组分别给药尿囊素铝片400mg,B组志愿者在服用尿囊素铝片的同时服用司帕沙星片400mg;C组志愿者在服用尿囊素铝片前2h服用司帕沙星片400mg;D组志愿者在服用尿囊素铝片前4h服用司帕沙星片400mg。采用HPLC法测定其司帕沙星血药质量浓度,比较其生物利用度的不同。结果:B、C组的生物利用度明显低于A组(P<0.01),D组的生物利用度与A组差异无显著性(P>0.05)。结论:给药时间不同可严重影响司帕沙星片的生物利用度,最佳的服药方法应该是服用司帕沙星片后4h再服用尿囊素铝片。

OBJECTIVE To investigate the effect of staggered dosing of aldioxa on sparfloxacin absorption and find out an optimum dosage regimen. METHODS Healthy volunteers were randomized and divided into four groups. A 400 rng dose of sparfloxacin was administered alone for treatment A （control）. Treatments B, C and D included aldioxa 400mg. For treatment B, aldioxa was administered concurrently with sparfloxacin 300 mg. For treatment C, 400 mg sparfloxacin was given 2 h prior to aldioxa. Treatment D consisted of sparfloxacin 400 mg given 4h prior to aldioxa. Sparfloxacin concentrations in plasma were determined by HPLC assays. Relative bioavailability was measured by sparfloxacin concentrations. RESULTS Relative bioavailability of treatment B and C was obviously lower than treatment A （control） （P〈0. 01 ）hut it was no significant deviation between treatment D and A（P〉0. 05）. CONCLUSION Different administration time can seriously effect the hioavailahility of sparfloxacin. And the optimum dosage regimen is that aldioxa should be administered 4 h after sparfloxacin.