血液灌流对尿毒症透析患者IL-6、IL-8、TNF-α的影响

Effect of hemoperfusion on the serum levels of IL-6,IL-8 and TNF-α in hemodialysis patients with uremia

目的:探讨血液灌流(HP)串联血液透析(HD)对透析患者血清IL-6、IL-8、TNF-α的影响。方法:选30例维持性HD患者,采用自身对照法,行HD串联HP治疗设为(HD+HP)组,行常规血透设为HD组。分别测定两组治疗前后的IL-6、IL-8、TNF-α水平。结果:(1)(HD+HP)组治疗后TNF-a显著下降(P<0.05),IL-6、IL-8稍有下降,但无统计学意义(P>0.05)。(2)HD组治疗后TNF-α、IL-6、IL-8均略微上升,但差异无显著性。结论:常规血透治疗后患者血清IL-6、IL-8、TNF-α无下降,HP串联HD治疗后IL-6、IL-8略微下降,血清TNF-α明显下降,有利于改善尿毒症患者的细胞免疫功能。

Objective：To investigate the effect and clinical significance of hemoperfusion （HP） on the serum levels of IL-6,IL-8 and TNF-α in hemodialysis CHD） patients with uremia.Methods：With the self-controlled method,30 maintenance hemodialysis patients enrolled in this study were divided into two groups,which were treated with the combined treatment of hemodialysis and hemoperfusion as HD plus HP group and with hemodialysis alone as HD group.The serum levels of IL-6,IL-8 and TNF-α were detected respectively before and after the treatment.Results：（1）After the treatment, the serum level of TNF-α in the HD plus HP group was decreased significantly （P〈0.05）;the serum levels of IL-6 and IL-8 decredsed slightly without statistically significant differenct （P〈0.05）.（2）AII the serum levels of TNF-α,IL-6 and IL-8 were increased slightiy,but without significant difference.Condusion：Hemodialysis has no effects on the serum levels of IL-6,IL-8 and TNF-α.The combined treatment hemodialysis and hemoperfusion can safely and effectively clear the serum level of TNF-αso it is benefical to correct the abnormal immune status in the uremic patients.