某院2005年住院结核病人耐药情况分析

Analysis of Anti-TB Drugs Resistance Among in-Patients in 2005

目的：了解2005年某市结核病防治院住院结核病人的耐药情况，从地域分布、年龄、正规用药角度探讨产生耐多药结核病（MDR—TB）原因。方法：回顾性调查2005年收治的333例结核菌培养阳性病人地域分布、年龄分布、抗痨用药史，并对全部培养阳性菌进行菌型鉴定及药物敏感性试验。结果：初始耐药率为20．85％，城市、县镇、乡村分别为20．00％、13．89％、25．67％。获得性耐药率为85．42％，城市、县镇、乡村分别为65．52％、88．24％、96．00％。〈25岁、25～50岁、〉50岁年龄分布MDR—TB初始耐药例数分别为4例、4例、3例，获得性耐药例数分别为3例、17例、5例。正规与不正规用药者MDR—TB耐药率分别为19．05％、28．00％。结论：某市结核病防治院住院结核病人获得性耐药率及MDR—TB获得性耐药率在地域分布上乡村〉县镇〉城市，在年龄分布上25—50岁组获得性MDR—TB明显增高，不正规用药者MDR—TB获得性耐药率明显增高。应加强乡镇人口治疗管理，重视对初治病人的结核菌培养及药敏试验。

Objective： To investigate resistant situation to anti- TB drugs among in- patients in A Anti -TB Hospital in 2005 and the reason of drugs resistance among patients from year,area,standard treatment. Methods： Analysis was conducted on laboratory data concerning mycobecterial type identification test and drug susceptibility test. Results： The total initial drug resistance rate was 20.00%, 13.89% ,25.67%, the total acquired drug resistance rate was 65.52% ,88.24% ,96.00% respectively for patients from cites , towns, rural area. Conclusion： Resistance to Anti - TB drugs was the highest among rural in - patients of the hospital. In order to control TB, must improve the detection and management for TB in rural and towns population.