耐甲氧西林葡萄球菌分布及多重耐药株分析

Distribution of MRS and Multidrug Resistant Colony

目的 探讨耐甲氧西林葡萄球菌（MRS）的流行分布和多重耐药趋势，防止MRS的暴发流行和采取有效的治疗措施。方法 细菌鉴定采用API Staph和TH-16S鉴定编码管，药敏试验采用ATB-STAPH5，MRS检测用稀释法和K—B法，数据处理用SPLM3．0分析软件。结果 两年耐甲氧西林金黄色葡萄球菌（MRSA）和耐甲氧西林表皮葡萄球菌（MRCNS）分离率分别为38．09％、20．00％和87．65％、89．00％，并随着年龄的增加MRS感染者增多；分离的金黄色葡萄球菌中MRSA的分离率为28．26％，而表皮葡萄球菌、溶血葡萄球菌、人葡萄球菌、腐生葡萄球菌腐生亚种等菌株中MRCNS的分离率均〉80％，MRS可引起各部位的感染；有〉30oA的MRSA耐多种抗菌药物，有11．87％～13．75％的MRCNS菌株对多种抗菌药物耐药。结论 我院MRSA分离率低于国家细菌耐药性监测网的结果，MRCNS的分离率和国家细菌耐药性监测网的结果基本相同。

OBJECTIVE To find out the prevalent distribution and multidrug resistance trend of meticillin-resistant Staphylococcus （MRS） and to prevent fulminant prevalence of MRS and opt for effective therapeutic means. METHODS The bacterium was identified by the way of API Staph and the TH-16S＇s coding tube. The antimicrobial susceptibility testing was adoped by ATB-STAPH5 and MRS was examined by dilution and K-B. All statistical analyses were performed using SPLM 3.0 software. RESULTS The isolation rate of meticillin-resistant S. aureus （MRSA） and meticillin-resistant coagulase negative Staphylococcus （MRCNS） was 38. 09 %, 20. 00% and 87.65%, 89.00%, respectively in 2 years. Along with the age of patients, the infection from MRS was increasing. The isolation rate of MRSA was 28-26%, but that of MRCNS was more than 80% from S. epidermidis, S. haemolyticus, S. hominis, and S. saprophyticus subsp saprophyticus. All parts of our body earl be infected by MRS. The more than 30% MRSA were multidrug resistant and the approximately 11.87-13.75% MRCNS were also multidrug resistant. CONCLUSIONS The isolation rate of MRSA from national surveillance network is not different with that of MRCNS.