摘要
血红素氧合酶-1(HO-1)是血红素氧合酶的诱导型,能催化血红素分解生成CO、胆红素和铁。这三种代谢产物通过多种机制对心血管系统产生保护作用,包括抗氧化应激、抗炎症损伤、抗细胞增殖、抗凋亡、抑制血小板聚集、调节血管张力及参与细胞内信号传递等。HO-1在多种心血管疾病中均有适应性表达,并在防治这些心血管疾病方面发挥重要作用。
Heme oxygenase-1 （ HO-1 ） is an inducible isoform of heme oxygenase, it can degrade heme into carbon monoxide, bilirubin and iron. These metabolic products protect the cadiovascular system via many mechanisms, including anti-oxidative stress, anti-inflammation injury, anti-proliferation of cells, anti-apoptosis, supressing platelet aggregation, regulating the tension of vessels and participating in the intracellular signal trans- duction, etc. HO-1 exhibits its adaptive expression in many cadioyascular diseases, and play an important part in the prevention and cure of them.
出处
《国际内科学杂志》
CAS
2007年第1期6-9,56,共5页
International Journal of Internal Medicine
基金
四川省科学技术厅2004(6)号
04JY029-021-3
