细胞色素P450 2D6与吸烟所致肺癌易感性的关系研究

Relation between cytochrome P450 2D6 and lung cancer susceptibility caused by smoking

细胞色素P450 2D6(CYP2D6)是肝脏中重要的Ⅰ相代谢酶,参与烟草中特异性亚硝胺类如4-甲基亚硝胺-1,3-吡啶基-1-丁酮(NNK)及烟碱的代谢,可能涉及吸烟引起的肺癌变过程。对其生物学特性、结构功能和基因多态与肺癌易感性的关系等方面的研究,有助于深入理解CYP2D6基因多态性对个体肺癌易感性的重要影响,并从基因-环境交互作用的角度,更好地进行危险度评价。

Cytochrome P450 2D6（CYP2D6） is one of the prominent phase 1 metabolizing enzymes in hepatic tissue, and is responsible for metabolically activating the tobacco-specific nitrosamine such as NNK and nicotinamide to highly reactive metabolites, so it may play a role in lung cancer. The study of its biological characters, structure function and the relationship beween CYP2D6 genetic polymorphisms and lung cancer susceptibility can redound to understand the significant influence of CYP2D6 on lung cancer susceptibility. Furthermore from the point of view of interaction between gene and environment it can evaluate the lung cancer risk accurately.