替加色罗联合氟哌噻吨美利曲辛治疗功能性消化不良的临床评价

Clinic evaluation on function dyspepsia treated with tagaserod combined with flupentixolmelitracen

目的探讨替加色罗联合氟哌噻吨美利曲辛治疗功能性消化不良（FD）的临床疗效。方法132例FD患者均经汉密尔顿焦虑量表（HAMA）和汉密尔顿抑郁量表（HAMD）进行精神心理学评定诊断为精神心理异常，用配对分组法分为治疗组、对照组各66例，治疗组给予替加色罗联合氟哌噻吨美利曲辛治疗，对照组给予奥美拉唑和莫沙必利治疗，疗程为4周。4周后重新评定上述量表总分和临床症状缓解情况，并进行评价和对比。结果两组消化道症状改善总有效率分别为90．9％、65．2％，组间比较差异有统计学意义（P〈0.01）；治疗组精神量表总分治疗前后比较差异有统计学意义（P〈0.01），对照组差异无统计学意义（P〉0.05）。结论替加色罗联合氟哌噻吨美利曲辛治疗FD对缓解消化道症状和改善心理异常疗效显著，FD患者的消化道症状与精神心理因素有关。

Objective To observe the clinical efficacy of tagaserod combined with flupentixolmelitraeen to treat patients with function dyspepsia （FD）. Methods One hundred and twelve patients with FD were evaluated to be psychological abnormal with Hamihom anxiety scale （HAMA） and Hamihom depression rating scale （HAMD）, and were divided into therapy group and control group according to a case-control study. Sixty-six eases of therapy group were treated with tagaserod combined with flupentixolmelitracen for 4 weeks, 66 cases of control group were treated with omeprazole combined with mosapride for 4 weeks. All were evaluated again with HAMA and HAMD after treatment, clinical symptom and efficacy were compared between two groups. Results The effective rates were 90.9% in therapy group and 65.2% in control group （P〈 0.01 ）. The scores of psychological scales in therapy group were significant difference between before and after treatment （P 〈 0.01）, those in control group were no difference （P 〉 0.05）. Conclusion Tagaserod combined with tlupentixolmelitracen is notably effective on FD. Digestive symptoms in patients with FD are related to psychological factors.