Ki-67在宫颈HPV感染相关病变诊断中的应用

The application of differential diagnosis for Ki-67 in cervix of HPV infectian

目的探讨Ki-67在宫颈人乳头瘤病毒(HPV)感染相关病变诊断中的应用。方法对128例病例首先进行组织学诊断、HPV原位杂交检测分为慢性宫颈炎、尖锐湿疣、上皮内瘤变(CIN)、宫颈鳞状细胞癌四组病变,再用免疫组化方法检测Ki-67。结果4组病变Ki-67的阳性率不同,分别为慢性宫颈炎(36.56%)、尖锐湿疣(55.77%)、上皮内瘤变(75.00%)、宫颈鳞状细胞癌(100%)。而且阳性信号分布位置也不同,并随着病变级别的增高而阳性信号强度也增强。结论HPV感染可以使宫颈上皮获得较高的增殖活性,病变级别越高增殖活性也越高。

Objective To investigate the diagnostic of Ki - 67 in cervix of HPV infection. Methods 128casea with surpected of HPV infection were include in this study.First all the cases can be devided into four gronps： chronic cervicitis, verruca acuminate,cervical intraepitbelial neoplasia （CIN） and cervical cacinoma by light microscopy and HPV （ISH）. And then Ki - 67 were detected by immunohistocbemistry. Results The positive rates of Ki - 67 detection in four groups were different, chronic cervicitis（36.56% ）, verruca acuminate（ 55.77 % ）, cervical intraepithelial neoplasia （CIN） （75.00%） and cervical cacinoma（ 100% ）. The positive site of Ki - 67 is different in different groups and it was higher in high grade cases. Conclusion The infection of HPV results in a more proliferative activity in cervical epithelium and this effect is higher in high grade cases.