焦炉工血中脂质过氧化水平与神经行为变化的关系

Relationship between lipid peroxidation in blood and neurobehaviorai function changes in coke oven workers

目的 探讨焦炉工体内脂质过氧化水平及其与神经行为的变化。方法 将134名焦炉工分为炉底组35名、炉侧组49名、炉顶组50名，以36名原材料处工人为对照组进行神经行为功能测试，并检测血中总超氧化物歧化酶（T-SOD）活力，谷胱甘肽（GSH）、丙二醛（MDA）含量。结果 焦炉工血中T-SOD活力和GSH含量均明显低于对照组，差异有统计学意义（P〈0．01），疲惫-惰性、紧张-焦虑、忧郁-沮丧、有力-好动、数字跨度等指标明显低于对照组，差异有统计学意义（P〈0．05）；而MDA含量明显高于对照组，差异有统计学意义（P〈0．01）；相关分析表明，神经行为改变与脂质过氧化指标间有相关关系，但相关系数均小于0．25，相关关系较弱。结论 焦炉工体内脂质过氧化水平升高，并与其神经行为改变共存。

Objective To explore the coincidence of lipid peroxidafion and neurobehavioml function changes in coke oven workers. Methods One hundred and thirty-four coke oven workers were divided into three groups： 35 in the oven-bottom group, 49 in the oven-side group and 50 in oven-top group. WHO recommended NCTB was performed on coke oven workers and 36 controls from material conservation department. The contents of total superoxidedismutases （T-SOD）, glutathione （GSH） and malondialdehyde （MDA） in blood were determined by test kits. Results Compared with the controls, the coke oven workers showed lower levels ofT-SOD and GSH（P〈0.01）, significantly higher MDA levels in blood （P〈0.01）, higher score on negative mood state, lower scores on positive mood state, and poorer performance in NCTB test（P〈0.05）. Further analysis revealed that there was a weak positive correlation between neurobehavioral function changes and the level of lipid peroxidation with a coefficient lower than 0.25. Conclusion The level of lipid peroxidation in coke oven workers＇ blood is increased and coincided with neurobehavioml function impairment.