摘要
目的探讨原发性中枢神经系统淋巴瘤(PCNSL)的临床特征、治疗及预后。方法对43例 PCNSL 患者的临床资料进行回顾性分析。结果 PCNSL 患者临床表现无特异性,颅内压增高、神经功能缺失为常见症状。本组患者中位生存时间18.0个月(95% CI 14.2~21.8个月)。Cox 回归分析显示室管膜、脑膜受累与否是影响预后的因素(P=0.002)。结论 PCNSL 预后差且术前诊断困难,其最佳治疗方案仍在探索之中。
Objective To explore the clinical characteristics, therapy and prognosis of primary central nervous system lymphoma ( PCNSL). Methods Forty-three PCNSL patients were retrospectively analyzed. Results The most frequent PCNSL clinical presentations were an increased intracranial pressure, focal neurologic deficits. The median survival time of patients was 18.0 months ( 14. 2-21.8 months, 95% CI). Cox regression model analysis revealed that ependymal and leptomeningeal involvement was the only independent factor for overall survival ( P = 0. 002 ). Conclusions PCNSL is a aggressive disease with a poor prognosis and difficult to diagnose before operation. The optimal treatment modality for newly diagnosed PCNSL is still under investigation.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2007年第1期36-38,共3页
Chinese Journal of Neurology
关键词
淋巴瘤
中枢神经系统肿瘤
预后
Lymphoma
Central nervous system neoplasms
Prognosis