黏膜免疫佐剂及免疫途径研究进展

Progress on Mucosal Immune Adjuvants and Delivery Route

黏膜是病原体入侵的主要门户,黏膜表面有高度集中的淋巴组织,一个黏膜部位的免疫反应可以诱发所有黏膜效应组织免疫反应的出现。黏膜免疫还可以诱导全身免疫应答,是目前疫苗研究的新方向,但黏膜免疫佐剂及免疫途径的发展制约着黏膜免疫的效果。文章对黏膜免疫佐剂及其途径进行了综述。

Mucosal surface is major portal of entry for pathogens. Mucosa contains high concentration of lymphocytes. Immunization of one mucosal inductive site may induce mucosal immune responses in all mucosal effector tissues. Mucosal immunization was not only capable of eliciting potent mucosal responses and also systemic immune responses. At present,it is a new direction for vaccine development. Mucosal adjuvant and delivery route restrict the development of mucosal immunization. The mucosal adjuvants and delivery route were reviewed in this paper.