Effect of Salvia Miltiorrhiza on Expression of the MMP-2 9 in Tissue of Early Stage Acute Lung Injury in Rats with Severe Acute Pancreatitis

Objective:To investigate the effect of salvia miltiorrhiza on expression of the MMP-2、9 and TIMP-1、TIMP-2 in tissue of acute lung injury of severe acute pancreatitis(SAP).Methods:MMP-2、9 expression and changes of the lung were measured after the SAP rats were induced by retrograde injection of 5%sodium tauocholate into hepatopancreatic duct.The changes of those parameters were also measured after salvia miltiorrhiza was injected intramuscularly just after induction of SAP.Results:The level of MMP-2、9 in pancreas and lung in SAP group were significantly higher than those in sham;The level of MMP-2、9 in salvia miltiorrhiza group were significantly lower than those in SAP group. Conclusion:MMP-2、9 were overexpressed in Acute lung injury (ALI) induced by SAP, salvia miltiorrhiza downregulates MMP-2、9 expression and decreased injury of lung tissue.

Objective：To investigate the effect of salvia miltiorrhiza on expression of the MMP-2,9 and TIMP-1, TIMP-2 in tissue of acute lung injury of severe acute pancreatitis（SAP）. Methods： MMP-2,9 expression and changes of the lung were measured after the SAP rats were induced by retrograde injection of 5% sodium tauocholate into hepatopancreatic duct. The changes of those parameters were also measured after salvia mihiorrhiza was injected intramuscularly just after induction of SAP. Results ： The level of MMP-2,9 in pancreas and lung in SAP group were significantly higher than those in sham; The level of MMP-2,9 in salvia miltiorrhiza group were significantly lower than those in SAP group. Conclusion. MMP-2,9 were overexpressed in Acute lung injury （ALI） induced by SAP, salvia miltiorrhiza downregulates MMP-2,9 expression and decreased injury of lung tissue.