一氧化氮在充血性心力衰竭患者血浆中含量变化及意义的探讨

The probe on the change and its significance of plasma nitric oxide in patients with congestive heart failure

为了探讨一氧化氮（ＮＯ）在充血性心力衰竭（ＣＨＦ）患者血浆中含量变化及其意义，应用比色法测定７０例ＣＨＦ患者治疗前后血浆ＮＯ水平，结果显示：ＣＨＦ患者治疗前、后血浆ＮＯ均显著高于对照组（均Ｐ＜０．０１），不同心功能分级组间ＮＯ有显著性差异（均Ｐ＜０．０１）。治疗后较治疗前心功能平均改善１．３级，且血浆ＮＯ下降有统计学意义（Ｐ＜０．０５）。提示：①ＮＯ可作为判定ＣＨＦ程度的指标；②ＮＯ在ＣＨＦ病理生理改变中起重要作用。

In order to study the change and the significance of plasma nitric oxide(NO) in patients with congestive heart failure(CHF),the plasma NO was measured in 70 patients with CHF before and after the treatment.The results showed:before and after the treatment,the plasma NO increased remarkabaly compared with the control group(all P<0.01).After treatment the plasma NO decreased significantly(P<0.05).Conclusions:①The plasma NO can he used as a parameter of CHF degree,②NO plays an important role in the pathophysiologic changes of CHF.