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心室颤动的时-频分析和胺碘酮的作用 被引量:2

Time-frequency Analysis of Ventricular Fibrillation And the Effects of Amiodarone
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摘要 研究心室颤动时主导频率的动态性空间时间变化。在19只犬中建立正交心电图和心脏电除颧系统;诱发心室颤动持续10-30s;使用时-频分析法分析心室颤动时频率的时频变化。另有4只犬在诱发心室颤动后静注胺碘酮100mg以观察主导频率的改变。结果显示:在427个10sVF和335个30sVF的试验中,主导频率的变化与平均频率相差12%~18%;79个使用胺碘酮的试验中,主导频率的均值和变异性均降低。表明:在10~30s心室颤动时心电图主导频率有明显和持续性的变异,胺碘酮可减小心室颤动时的频率和变异。 This study is to quantify time-varying dominant frequencies in electrocardiogram (ECG) during the ventrlcular fibrillation (VF). Orthogonal ECG (sagittal, x; transverse, y; and longitudinal, z) and the transvenous two-leads defibrillation systems were set in 19 dogs. Time-frequency analysis was used to assess changes in the dominant frequency within ECG recorded in dogs during trials of 10-30 s of VF. In 4 additional dogs, the dominant frequencies were compared during 10s of VF before and after administration of amiodarone. Results showed that in the 427 trials of 10 s VF and 335 trials of 30 s VF, average variation in the dominant frequency was considerable, between± 12%-18%. The frequencies orthogonal ECG during 10 s VF were distributed symmetrically above and below the mean frequency like a normal distribution. In the 79 trials with administration of amiodarone during 10 s VF in all three ECG, the mean frequencies decreased from 6.5 (x),7.4 (y) and 7.0 Hz (z) to 6.1,6.4 and 6. 3 Hz (P(0. 01), respectively, and the variation in dominant frequencies decreased from 1.18, 1.38 and 1.19 to 0.98,1.11 and 1.02 Hz (P(0.05) respectively. The results confirmed that the frequencies of 10-30 s VF in ECG vary considerably and continuously, and amiodarone decreases this variation.
出处 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2007年第1期45-49,共5页 Journal of Biomedical Engineering
关键词 心室颤动 时-频分析 胺碘酮 心电图 Ventricular fibrillation(VF) Time-frequency analysis Amiodarone Electrocardiogram (ECG)
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