替硝唑可生物降解聚乳酸缓释凝胶的制备

Preparation of Biodegradable and Sustained Release Gel of Tinidazole

采用聚乳酸[poly（DL-lactide）]制备替硝唑牙周缓释凝胶，考察聚合物分子量、浓度、溶剂和载药量等因素的影响，应用正交实验优选最佳制备工艺条件。结果表明，以N-甲基-2-吡咯烷酮（NMP）为溶剂，poly（DL-lactide）[DL-PLA]5700浓度为30：70，载药量为4％～6％时的工艺条件较优。

The objective of this study was to prepare a biodegradable poly （DL-lactide） injectable gel of tinidazole. The formulation parameters evaluated in this study included polymer molecular weight, polymer concentration, solvent and drug loading, and orthogonal design was used to optimize the formulation. The preferable formulation was that 30%（w/w） poly（DL-lactide） （MW is 5 700） dissolved in 70% （w/w） N-methyl-2- pyrrolidone with 4%-6% （w/w） tinidazole.