摘要
腹膜透析中用作透析充分性的指标主要有尿素清除指数(KT/Vurea)和肌酐清除率(Ccr)。为了探讨这两个指标是否能够全面准确地反映腹膜透析充分性,我们依据三孔模型的理论建立物质跨腹膜转运的数学模型,描述了单次透析过程中水和溶质在透析液中的浓度和总量随时间的变化规律。我们发现,分子量不同的溶质清除速率和清除总量并不一定存在相关关系;尿素和水钠的清除量之间有本质的区别。尿素、肌酐的清除既不能代表大、中分子的清除,也不能代表水盐的清除。因此,KT/Vurea和Ccr可能不适合单独用来评价腹膜透析充分性。
Urea clearance index (KT/Vurea) and creatinine clearance weekly (Ccr) are main indexes to evaluate dialysis adequacy. In order to discuss whether they are suitable to evaluate peritoneal dialysis adequacy, we applied trans-peritoneum transport kinetic model and explored the transport characteristics of fluid and various solutes. We found that: 1. There was no specific relationship among the removal of solutes with different molecular weights: 2. There was significant difference between urea removal and fluid and sodium removal. Our results suggest that urea and creatinine removal do not represent other solutes and fluid removal. KT/Vurea and Ccr may thus not suit to be used alone to evaluate peritoneal dialysis adequacy.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2007年第1期140-144,共5页
Journal of Biomedical Engineering
基金
教育部长江学者奖励计划
教育部教育振兴行动计划专项基金(985工程)资助(36-1)
关键词
尿素清除指数
肌酐清除率
腹膜透析充分性
数学模型
Urea clearance index(KT/Vurea) Creatinine clearance weekly(Ccr) Peritoneum dialysis adequacy Kinetic model