成纤维细胞生长因子与造血调节研究进展
摘要
成纤维细胞生长因子(FGFs)属于肝素一结合多肽家族,具有影响细胞增殖、分化、凋亡和迁移等多种功能。FGFs受体表达于各类造血干/祖细胞和基质细胞。FGFs既可维持造血微环境稳定,也能促进造血干/祖细胞增殖,维持它们的原始表型。此外,FGFs还能协同其他造血生长因子增强造血干/祖细胞体外克隆的形成,有助于造血干/祖细胞的体外扩增,具有潜在的临床应用价值。
出处
《国际输血及血液学杂志》
CAS
2007年第1期35-37,共3页
International Journal of Blood Transfusion and Hematology
基金
国家自然科学基金资助项目(30260039)
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