期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

造血负性调控因子与再生障碍性贫血发病机制的研究进展 被引量：5

原文传递
导出
摘要 再生障碍性贫血患者的骨髓和外周血中存在细胞因子水平的变化，其中重要的负性调控因子有肿瘤坏死因子-α、γ-干扰素、转化生长因子-β和一氧化氮等。现就这几种重要的负性调控因子与再障发病机制的研究进展作一综述。
作者 庞妍（综述） 肖扬（审校）
机构地区 广州军区广州总医院血液科
出处 《国际输血及血液学杂志》 CAS 2007年第1期55-57,共3页 International Journal of Blood Transfusion and Hematology
基金 广东省自然科学基金项目（编号：5000138）
关键词 贫血 再生障碍性 肿瘤坏死因子 Γ-干扰素 转化生长因子-Β
分类号 R752.120.5 [医药卫生—皮肤病学与性病学]
  • 相关文献

参考文献20

  • 1Dufour C, Corcione A, Svahn J, et al. TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro. Blood, 2003, 102 (6): 2053-2059.
  • 2Hara T, Ando K, Tsurumi H, et al. Excessive production of tumor necrosis factor-alpha by bone marrow T lymphocytes is essential in causing bone marrow failure in patients with aplastic anemia. Eur J Haematol, 2004,73 (1):10-16.
  • 3Verma A, Deb DK, Sassano A,et al. Cutting edge : activation of the p38 mitogen-activated protein kinase signaling pathway mediates cytokine-induced hemopoietic suppression in aplastic anemia. J Immunol, 2002, 168 (12):5984-5988.
  • 4Martinez-Jaramillo G, Flores-Figueroa E, Gomez-Morales E, et al. Tumor necrosis factor-alpha levels in long-term marrow cultures from patients with aplastic anemia: modulation by granulocyte-macrophage colony-stimulating factor. Am J Hematol, 2001, 68 (3):144-148.
  • 5Dubey S, Shukla P, Nityanand S. Expression of interferon-gamma and tumor necrosis factor-alpha in bone marrow T cells and their levels in bone marrow plasma in patients with aplastic anemia. Ann Hematol, 2005,84 (9):572-577.
  • 6Kast RE, Altschuler EL. Proposal for using small molecule tumor necrosis factor-alpha lowering agents, possibly bupropion, in aplastic anemia. Med Hypotheses, 2005, 65(2) : 374-376.
  • 7Geissler K, Kabrna E, Kollars M, et al. Interleukin-10 inhibits in vitro hematopoietic suppression and production of interferon-gamma and tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with aplastic anemia. Hematol J, 2002,3(4) :206-213.
  • 8Wenxin L,Jinxiang F,Yong W. Expression of membrane-bound IL-15 by bone marrow fibroblast-like stromal cells in aplastic anemia. Int Immunol 2005,17 (4) : 429-437.
  • 9Welsh JP, Rutherford TR, Flynn J, et al. In vitro effects of interferon-gamma and tumor necrosis factor-alpha on CD34+ bone marrow progenitor cells from aplastic anemia patients and normal donors. HematolJ, 2004, 5(1):39-46.
  • 10Zeng W, Miyazato A, Chen G, et al. Interferon-gamma-induced gene expression in CD34 cells: identification of pathologic cytokine-specific signature profiles. Blood, 2006, 107 (1): 167-175.

同被引文献54

  • 1甘欣锦,蒋楠.浅议再生障碍性贫血的中医病因病机[J].国医论坛,2006,21(1):13-14. 被引量：1
  • 2黄永兰,黄绍良.儿童再生障碍性贫血免疫介导发病机制及治疗进展[J].中华儿科杂志,2006,44(2):153-155. 被引量：13
  • 3邵宗鸿,袁烨.再生障碍性贫血免疫发病机制及免疫治疗[J].中国实用内科杂志：临床前沿版,2006,26(2):252-255. 被引量：83
  • 4郑邈,刘文励,孙汉英.再生障碍性贫血的诊断和治疗[J].中国医师进修杂志（内科版）,2006,29(11):6-10. 被引量：3
  • 5Young NS, Scheinberg P, Calado RT. Aplastic anemia [ J ]. Curr Opin Hematol,2008,15 (3) : 162 - 168.
  • 6Briot D,Mace- Aime G, Subra F,et al. Aberrant activation of stress- response pathways leads to TNF - alpha oversecretion in Fanconi anemia [J]. Blood,2008,111 (4) :1913 - 1923.
  • 7Gu Y, Hu Y, Liu C, et al. Interleukin (IL) - 17 promotes macrophages to produce IL - 8, IL - 6 and tumor necrosis factor - alpha in aplastic anemia [ J ]. Br J Haematol,2008,142 ( 1 ) : 109 - 114.
  • 8Solomou EE ,Keyvanfar K,Young NS. T - beta Thl transcription factor, is up - regulated in T cells from patients with aplastic anemia [ J ]. Blood ,2006,107 (10) :3983 - 3991.
  • 9Secchiero P, Zauli G. Tumor - necrosis - factor - related apoptosis - inducing ligand and the regulation of hematopoiesis[ J]. Curr Opin Hematol2008,15 ( 1 ) :42 - 48.
  • 10Hara T, Audo K, Tsunmi H, et al. Excessive production of tumor necrosis factor - alpha by bone marrow T lymplaocytes is essential in causing bone marrow failure in patients with aplastic anemia [ J ]. Eur J Haematol, 2004,73( 1 ) :10 - 16.

引证文献5

二级引证文献7

国际输血及血液学杂志
2007年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部