脾损伤患者自体脾组织移植术后血清tuftsin的变化

Changes of serum tuftsin after splenic autotransplantation in patients with splenic trauma

采用反相－高效液相色谱（ＰＲ－ＨＰＬＣ）法测定血清ｔｕｆｔｓｉｎ的含量，对３０例脾损伤自体脾组织移植术后近、远期患者的血清ｔｕｆｔｓｉｎ变化及全脾切除术后和对照组患者的同期变化进行了比较研究。结果显示：自体脾组织移植术后近期，血清ｔｕｆｔｓｉｎ浓度明显下降，但术后远期可恢复接近正常水平，而全脾切除术后却呈进行性下降趋势。提示：自体脾组织移植术后的近期，脾功能仍处于低下状态，远期可获改善并保留了脾脏继续产生ｔｕｆｔｓｉｎ的功能。因此。

In order to observe the changes of serum tuftsin and evaluate splenic function after splenic autotransplantation, a comparative study of the changes of serum tuftsin in postoperative short and long periods was undertaken in 30 patients with splenic trauma (10 were treated with splenic autotransplantation and 20 with total splenectomy) and 10 normal controls with reverse phase high performance liquid chromatography (RP HPLC). It was found that the concentration of serum tuftsin in those patients treated with splenic autotransplantation was remarkably decreased in postoperative short period and restored normal in postoperative long period but it was progressively decreased in those patients treated with total splenectomy. These findings suggest that the splenic function is low in postoperative short period after splenic autotransplantation but it can be improved and the splenic function of producing tuftsin is maintained. So the splenic autotransplantation might be beneficial for maintaining the concentration of serum tuftsin and enhance the anti infective capacity of human body.