白癜风发病与自身免疫性甲状腺病的相关性探讨

The Study on the Association Between the Prevalence of Autoimmune Thyroid Disease and Vitiligo

目的探讨白癜风与自身免疫性甲状腺病(AITD)的发生是否存在相关性。方法用化学发光分析法测定38例白癜风患者和35名正常人群的甲状腺功能(包括抗甲状腺球蛋白抗体和抗甲状腺过氧化物酶抗体),比较白癜风患者和正常对照组间甲状腺自身抗体阳性率,同时比较甲状腺自身抗体阳性的白癜风患者与甲状腺自身抗体阴性的白癜风患者间AITD患病率。结果白癜风患者T3和T4与正常对照组比较差异无显著性(P>0.05),而白癜风患者FT3和FT4与正常对照组比较差异均有显著性(P<0.05)。白癜风患者血清TSH与正常对照组比较差异有显著性(P<0.01)。白癜风患者甲状腺自身抗体阳性率与正常对照组比较均有增高趋势(P<0.05)。甲状腺自身抗体阳性的白癜风患者AITD患病率(41.18%)与甲状腺自身抗体阴性的白癜风患者(9.52%)间比较明显增高(P<0.05)。结论白癜风的发病与甲状腺功能的改变和自身免疫有着密切的联系。

Objective To explore the association between the presence of autoimmune thyroid disease（AITD） and vitiligo. Methods The study group included 38 vitiligo who were treated in the outpatient department of the hospital. The control group included 35 healthy people. Thyroid function and anti-thyroid autoantibodies tested by chemiluminescence immunoassay were statistically analyzed by X2 test. We compared the prevalence of AITD in vitiligo patients between those whose anti-thyroid autoantibodies were positive and negative. Results The levels of T3 and T4 in the serum of patients with vitiligo were not significantly different from the normal controls （ P〉0.05 ） . Compared to normal controls , the levels of FT 3 and FT 4 was significantly increased （P〈0.05 ） ,whereas the level of TSH decreased （P〈0.01 ）. Compared with those whose anti-thyroid autoantibodies were negative, the vitiligo patientswhoseanti-thyroidautoantibedieswerepostiveandhadahigherprevalenceofAITD （ 41.18 % , 9.5 2 % , P〈0.05 ）. Conclusion Disfunction of thyroid and autoimmunity might be related to the pathogenisis of vitiligo.