急性脑梗死患者血清S100β蛋白和C反应蛋白含量变化的研究

Study of the change of serum S100β protein and CRP content in patients with acute cerebral infarction

目的探讨急性脑梗死(ACI)患者血清S100β蛋白和C反应蛋白(CRP)含量变化的意义及其机制。方法测定54例ACI患者、21名正常对照者血清S100β蛋白和CRP的含量,观察比较ACI患者在不同病情、不同梗死面积时的血清S100β蛋白和CRP含量变化,采用Speannan法对二者进行相关性分析。结果ACI患者血清S100β蛋白[(0.442±0.207)μg/L]和CRP[(16.35±7.51)mg/L]浓度明显高于正常对照组[(0.058±0.022)μg/L,(5.06±2.03)mg/L](均P<0.05)。并且随着神经功能缺损程度评分的增高,血清S100β和CRP含量亦明显升高;S100β蛋白水平和CRP水平呈正相关(r=0.887,P<0.01)。结论S100β蛋白与CRP一样可作为预测ACI患者病情严重程度及预后的生化指标,二者相结合进行评价意义更大。

Objective To investigate the change and its mechanism of serum S100β protein and C-reactive protein （CRP） content in patients with acute cerebral infarction（ACI）. Methods The content of serum S100β and CRP in 54 patients with ACI and 21 normal control were measured. The changes of S100β and CRP were compared with patients of different pathogenetic condition and infarction sige. The correlation analysis between S100β and CRP was also made. Results The level of serum S100β and CRP in patients with ACI increased significantly compared with control group （all P 〈 0.05 ）. The level of serum S100β and CRP increased with the score of neurofunction detection and infarction area. The level of serum S100β has positive correlation with the level of CRP. Conclusions The S100β protein can be one of the index to predict the neurofunction of ACI, as well as CRP protein do. There is the more significance if two factors combine with each other.