依卡倍特钠联合法莫替丁治疗胃溃疡疗效观察

Clinical efficacy of ecabet sodium and famotidine in treatment of gastric ulcer

目的探讨新药依卡倍特钠对法莫替丁治疗胃溃疡的促进作用及安全性。方法选择符合诊断标准的胃溃疡126例,随机双盲分为试验组(A组,n=64)和对照组(B组,n=62),两组患者基础临床特征相似,试验组口服依卡倍特钠1 g,2/d及法莫替丁20 mg,2/d,对照组口服法莫替丁20 mg,2/d,疗程均为6周。记录两组患者症状改善情况及两组的不良反应,内镜下观察胃溃疡的愈合情况。结果试验组胃溃疡有效率为95.31%,对照组为93.55%,组间比较差异无统计学意义,但痊愈率依卡倍特钠组明显高于对照组(42.25%比20.31%,P<0.05),治疗1周依卡倍特钠组患者疼痛症状迅速缓解,与对照组比较差异有统计学意义(P<0.05),两组不良反应均轻微。结论依卡倍特钠联合法莫替丁治疗胃溃疡可提高治疗质量且安全性高。

Objective To investigate the effieacy of eeabet sodium plus famotidine in treatment of gastric ulcer. Methods One hundred and twenty-six patients with gastric ulcer were randomly divided into two groups . The patients in group A（ n =64） received ecabet sodiurn （1g bid） plus famotidine（20 mg bid） for 6 weeks. The patients in group B （ n = 64） received famotidine（20 mg bid） for 6 weeks. Improvement in symptoms and adverse effects were recorded. The cure rate was assessed by endoscopy. Results The effective rates of the two regimens showed no aignificant difference in the treatment of gastric ulcer（95.31% vs 93.55%, P 〉 0.05） .The cure rate of gastric ulcer in group A was higher than that in group B （42.25 % va20.31%, P 〈 0.05）. The combined therapy of ecabet sodium and famotidine relieved the gastric pain more rapidly than the single famotidine therapy （ P 〈 0.05）. The patients had good tolerance and experienced mild adverse events in the both groups. Conclusions Ecabet sodium combined with famotidine is highly effective and safe in the treatment of gastric ulcer.