IL-6及Sgp80、Sgp130与Graves’病及其骨代谢关系的临床研究

Study on the Relationship Between Serum IL-6,Sgp80,Sgp130 Levels and Bone Metabolism in Patients with Graves' Disease

目的:探讨IL-6及其可溶性受体(Sgp80、Sgp130)与G raves’病(GD)及其骨代谢的关系。方法:对78例GD患者的血清行双抗体放射免疫分析检测血清IL-6,ELISA检测血清Sgp80、Sgp130。采用双能X线骨密度测定仪测定骨密度。结果:未治疗组、部分缓解组、缓解组的血清IL-6、Sgp130均明显高于正常对照组(P<0.05),未治疗组、部分缓解组的血清Sgp80明显高于缓解组和正常对照组(P<0.05)。血清Sgp80与FT3、FT4、血磷(P)、血骨钙素(BGP)、尿羟脯胺酸(HYP)均成正相关。结论:血清IL-6及Sgp80、Sgp130与GD及其骨代谢的发病密切相关,血清Sgp80可作为观察GD治疗情况的重要指标,GD患者的皮质骨、松质骨有均等机会发生骨量丢失,骨形成与骨吸收的增加可能均为原发性的,而非骨形成继发于骨吸收。

Objective To investigate the relationship between serum IL -6, Sgp80, Sgp130 levels and bone metabolism in patients with Graves＇ disease. Mothods Serum levels of IL -6 （with RIA）, Sgp80, Sgp130 （with ELISA） as well as BMD of proximal femur region were determined in 78 patients with Graves＇ disease （26 not treated yet, 26 partially remitted and 26 in remission） and 30 controls. Results The serum IL -6 and Sgp130 levels in all the patients with Graves＇ disease were significantly higher than those in controls （P 〈 0.05）. The serum Sgp80 levels in the patients not treated and partially remitted were significandy higher than those in patients in remission and controls （P 〈 0.05）. Serum Sgp80 levels were positively correlated with serum FT3, FT4, phosphorous, BGP and urinary hydroxy proline levels. BMD of the proximal femur region in patients partially remitted were much lower than that in controls （P 〈 0.05）. Conclusion Serum Sgp80 level might be taken as an important parameter in studying of Graves＇ disease. Bone loss, beth cortical and trabecular, occurred in patients with Graves＇ disease. In crease of bone formation as well as bone resorption were primary, not secondary to each other.