2型糖尿病微血管病变患者血小板平均体积与尿清蛋白排泄率的关系

Association between mean platelet volume and urinary albumin excretion rate in type 2 diabetes mellitus patients with micrangium disease

目的探讨血小板平均体积（MPV）及尿清蛋白排泄率（UAER）在糖尿病微血管病变患者中测定的意义及关系。方法对67例糖尿病微血管病变患者分别采用全自动血细胞分析仪和免疫散射比浊法测定血小板平均体积及UAER，并与20例糖尿病无血管并发症组和30例正常对照组比较。结果糖尿病微血管病变组血小板平均体积（11．43±2．00）及UAER（2．07±0．62）均显著高于正常对照组8．69±1．85（P〈0．01）、0．97±0．18（P〈0．01）和糖尿病无血管并发症组9．02±1．91（P〈0．01）、1．05±0．23（P〈0．01）；而糖尿病无血管并发症组与正常对照组间血小板平均体积及UAER差异无统计学意义（P〉0．05）；糖尿病微血管病变患者大量清蛋白尿组MPV（12．29±2．11）显著高于正常清蛋白尿组10．02±0．90（P〈0．01）和微量清蛋白尿组11．08±1．82（P〈0．05），微量清蛋白尿组显著高于正常清蛋白尿组（P〈0．05）。结论MPV及UAER的检测，对糖尿病微血管病变的发生、发展及早期诊断和治疗具有重要意义，是反映糖尿病微血管病变范围及病变程度的指标。

Objective To study the change of mean platelet volume and urinary albumin excretion rate and relationship between them in diabetes mellitus patients with micrangium disease. Methods Mean platelet volume was measured with MEK-6318K automated blood cell counter and urinary albumn excretion rate was measured with rate nepheiometry in diabetes mellitus patients with micrangium disease,and compared with those of 20 diabetes mellitus patients without vascular disease and 30 normal controls. Results The mean platelet volume and urinary albumin excretion rate in diabetes mellitus patients with micrangium disease were 11.43± 2.00,2.07± 0.62, significantly higher than those in normal controls 8. 69±1.85 （P〈0. 01）,0.97±0. 18（P〈0.01）and in diabetes mellitus patients without vascular disease 9.02±1.91 （P〈0. 01 ）, 1.05 ± 0. 23 （P〈0.01） ; the mean platelet volume in diabetes mellitus patients with micrangium disease with macro-albuminuria were 12.29 ± 2. 11,significantly higher than those in diabetes mellitus patients with micrangium disease with normo-albuminuria 10.02±0. 90（P〈0. 01）and in diabetes mellitus patients with micrangium disease with micro-albuminuria 11.08 ± 1.82（P〈0.05） ;the mean platelet volume in diabetes mellitus patients with micrangium disease with micro-albuminuria was significantly higher than those in diabetes mellitus patients with micrangium disease with normo-albuminuria（P〈0. 05）. Conclusion The measurement of mean platelet volume and urinary albumin excretion rate is of clinical value of application and study in the early diagnosis or prevent and treatment of diabetes mellitus patients with micrangium disease.