胰腺十二指肠同源基因1的结构、表达调控与功能
被引量：1
摘要
胰腺十二指肠同源基因1（PDX-1）是编码调节与胰腺发育和β细胞特异基因表达有关的一种特异性转录因子，是胰腺干细胞分化、成熟过程中的第一个分子标记。PDX-1基因的活化可促进胰岛素的释放及β细胞重要基因的表达，也是胰腺干细胞分化为胰岛β细胞的必要条件之一。细胞因子、胰高糖素样肽1（GLP-1）等多种信号转导物质协同调节PDX-1基因的表达。探讨PDX-1的基因表达及生理功能，有助于理解胰腺干细胞向胰岛β细胞诱导分化过程，进一步评估其在糖尿病发生中的可能作用。
出处
《国际检验医学杂志》
CAS
2007年第1期35-37,共3页
International Journal of Laboratory Medicine
基金
国家自然科学基金项目（基金编号30270631和30370671）
参考文献14
-
1Wilson ME,Scheel D,German MS.Gene expression cascades in pancreatic development[J].Mech Dev,2003,120(1):65-80.
-
2Chakrabarti SK,James JC,Mirmira RG.Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor,Pdx1.Importance of chromatin structure in directing promoter binding[J].J Biol Chem,2002,277(15):13286-13293.
-
3Ozcan S,Mosley AL,Aryal BK.Functional expression and analysis of the pancreatic transcription factor PDX-1 in yeast[J].Biochem Biophys Res Commun,2002,295(3):724-729.
-
4Andersson AK,Borjesson A,Sandgren J,et al.Cytokines affect PDX-1 expression,insulin and proinsulin secretion from iNOS deficient murine islets[J].Mol Cell Endocrinol,2005,240(1-2):50-57.
-
5Stanojevic V,Yao KM,Thomas MK.The coactivator Bridge-1 increases transcriptional activation by pancreas duodenum homeobox-1 (PDX-1)[J].Mol Cell Endocrinol,2005,237(1-2):67-74.
-
6Kodama S,Toyonaga T,Kondo T,et al.Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice[J].Biochem Biophys Res Commun,2005,327(4):1170-1178.
-
7Li WC,Horb ME,Tosh D,et al.In vitro transdifferentiation of hepatoma cells into functional pancreatic cells[J].Mech Dev,2005,122(6):835-847.
-
8Liu HK,Green BD,Gault VA,et al.N-acetyl-GLP-1:a DPP IV-resistant analogue of glucagon-like peptide-1 (GLP-1) with improved effects on pancreatic beta-cell-associated gene expression[J].Cell Biol Int,2004,28(1):69-73.
-
9Qiu Y,Guo M,Huang S,et al.Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1,BETA2,and E47[J].Mol Cell Biol,2002,22(2):412-420.
-
10Stanojevic V,Habener JF,Thomas MK.Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300[J].Endocrinology,2004,145(6):2918-2928.
同被引文献49
-
1张雷,秦新裕.小鼠异种胰岛移植排斥反应研究[J].中华实验外科杂志,2006,23(1):43-44. 被引量：8
-
2吴娟利,赵小立.胰腺干细胞研究进展[J].细胞生物学杂志,2006,28(3):368-372. 被引量：3
-
3金洁娜,倪连松,郑景晨.胰腺干细胞诱导分化方法的研究进展[J].医学综述,2007,13(1):10-12. 被引量：2
-
4冯若鹏,张慧茹,窦忠英.胎猪胰岛源胰腺干细胞分离培养与诱导分化试验[J].中国农业科学,2007,40(3):582-587. 被引量：5
-
5TODOROV I,NAIR I, FERRERI K,et al. Multipotent progenitor cells isolated from adult human pancreatic tissue[J]. Transplant Proc ,2005,37(8) :3420-3426.
-
6KEN Z. Self-help for insulin cells[J]. Nature, 2004, 429 (6987):30 31.
-
7HUNZIKER E,STEIN M. Nestin-expressing cells in the pancreatic islet of Langerhans[J]. Biochem Biophys Res Commun,2000,271(1):116-119.
-
8SCHWITZGEBEL V M, SCHEEL D W, CONNERS J R, et al. Expression of neurogenin 3 reveals an islet cell precursor population in the pancreas[J]. Development, 2000, 127 (16) : 3533-3542.
-
9BROWNE D, HOOVER G K, COLE J D, et al. Initial experience with a second generation locking femoral nail: the Russell-Taylor reconstruction nail [J ]. Contemp Orthop, 1991,23(3) : 199-208.
-
10SOBKOWSKA E, WARCHALEWSKI J, NOWAKOWSKA K, et al. amino acid composition of cereal and oilseed[J]. Nahrung, 1973,17(3) :359-365.
引证文献1
-
1吴杭格,李碧春,王丽梅,宋海龙,兰海楠,赵小丽,郑鑫.胰腺干细胞的研究进展[J].中国兽医科学,2007,37(11):1000-1007.
-
1武革,吴美芬,郑坤杰,方烁,陈晓铭.利拉鲁肽对2型糖尿病大鼠胰岛β细胞凋亡及PDX-1表达的影响[J].基础医学与临床,2015,35(9):1256-1258. 被引量：2
-
2杨彤翰,张银甫,杨唐俊,梁平,李靖,左国华,杨清浩,何斌,冯嘉渝,龚自力.胰腺十二指肠肾脏一期联合移植五例报告[J].中华肝胆外科杂志,2001,7(9):540-542.
-
3杨毅,李蓬秋,王利,鲜杨,张学军,包明晶,张磊.2型糖尿病患者葡萄糖耐量试验后胰高糖素样肽1水平变化[J].临床荟萃,2014,29(5):509-511. 被引量：4
-
4王琳.2型糖尿病患者血清胰高糖素样肽1水平变化及意义[J].山东医药,2013,53(40):52-54. 被引量：3
-
5庞艳华,郝建宇,张文杰,郑长青.溃疡性结肠炎中信号转导和转录活化因子6的活化表达及作用[J].中华消化杂志,2007,27(10):679-681. 被引量：1
-
6倪莲芳,张志刚,卜定方,刘新民.Ⅱ类主要组织相容性抗原在博来霉素致大鼠纤维化肺组织中的表达[J].北京大学学报（医学版）,2008,40(5):514-518.
-
7谢超,洪天配.基于胰高糖素样肽1药物的胰腺安全性[J].中国医学前沿杂志（电子版）,2014,6(1):24-28. 被引量：3
-
8李晋,姜妙娜,贾玉杰.肝复康对肝纤维化大鼠肝组织JAK2和STAT3表达的影响[J].临床肝胆病杂志,2010,26(5):527-530. 被引量：4
-
9石志平,韩蕊,徐志芳,周亚茹.胰高糖素样肽1在非酒精性脂肪肝中的作用[J].中华肝脏病杂志,2015,23(3):234-237.
-
10洪源,兰孟东,王琦,张黎颖,刘秀财,李晓光,郝晓花,成军.丙型肝炎病毒非结构蛋白2反式激活蛋白的原核表达及多克隆抗体制备[J].中华传染病杂志,2009,27(4):217-220.
