糙叶败酱中环烯醚萜苷元成分抗结肠癌作用的实验研究

Effects of the iridoid aglycones from Patrinia scabra on colon cancer

目的:研究糙叶败酱中环烯醚萜苷元成分体外抗小鼠结肠癌细胞株C26作用和对小鼠结肠癌(C26)移植性肿瘤的作用。方法:采用四唑盐(MTT)比色法研究糙叶败酱中环烯醚萜苷元PS-Ⅰ和BJ3401对小鼠结肠癌细胞株C26生长的影响;于F1小鼠皮下注射小鼠结肠癌细胞株(C26)建立小鼠结肠癌移植性肿瘤模型,观察糙叶败酱中总环烯醚萜苷元对结肠癌移植性肿瘤小鼠的影响。结果:环烯醚萜苷元PS-Ⅰ、BJ3401可显著抑制小鼠结肠癌细胞株C26的生长,并且具有一定的剂量依赖关系;总环烯醚萜苷元可显著减轻荷瘤鼠瘤重。结论:糙叶败酱中环烯醚萜苷元具有抗结肠癌的作用。

Objective： To study the effects of the ifidoid aglyeones from Patrinia scabra on mouse colon cancer cell line C26 in vitro and on transplanting-tumor of mouse eolon cancer cell C26. Methods： The effects of the iridoid aglycones from Patrinia scabra （PS - I, BJ3401） on mouse colon cancer cell line C26 were studied by MTF experiment, the transplanting-tumor model of mouse colon cancer was established by hypodermic inoculating the mouse colon cancer cell lines C26 into the F1 mice. Results： The iridoid aglycones PS - I and BJ3401 could significantly inhibit proliferation of C26 cell line in a dose-dependent manner, gross iridoid aglycones could significantly lessen the weight of the transplanting-tumor in mice. Conclusion： The iridoid aglyeones from Patrinia scabra have anti-colon carcinoma activity.