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新型免疫抑制剂FTY720的研究进展 被引量:3

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出处 《广东医学》 CAS CSCD 北大核心 2007年第2期319-321,共3页 Guangdong Medical Journal
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参考文献20

  • 1KIUCHI M,ADACHI K,KOHARA T,et al.Synthesis and immunosuppressive activity of 2-aminopropane-1,3-diols and 2-aminoethanols[J].Med Chem,2000,43 (15):2 946 -2 961.
  • 2CHIBA K,YANAGAWA Y,MASUBUCHI Y,et al.FTY720,a novel immunosuppressant,induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats.Ⅰ.FTY720 selectively decreases the number of circnlating mature lymphocytes acceleration of lymphocyte homing[J].J Immunol,1998,160(10):5 037 -5 044.
  • 3MAYER K,BIRNBAUM F,REINHARD T,et al.FTY720 prolongs clear corneal allograft survival with a differential effect on different lymphocyte populations[J].British Ophthalmology,2004,88(7):915 -919.
  • 4SEDIAKOVA K,MUCKERSIE E,ROBERTSON M,et al.FIY720 in corneal concordant xenotransplantation[J].Transplantation,2005,79(3):297 -303.
  • 5夏宝森,李小康.FTY720:一个来源于冬虫夏草的新型免疫抑制剂[J].上海免疫学杂志,2002,22(2):79-81. 被引量:29
  • 6LAMONTAGNE K,LITFLEWOOD-EVANS A,SCHNELL C,et al.Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization[J].Cancer Res,2006,66(1):221 -231.
  • 7KLEMENS B,ROBERT L,SCHMOUDER A,et al.First human trial of FTY720,a novel immunomodulator,in stable renal transplant patients[J].Am Soc Nephrol,2002,13 (4):1 073 -1 083.
  • 8BILLICH A,BORNANCIN F,DEVAY P,et al.Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases[J].Biol Chem,2003,278(48):47 408 -47 415.
  • 9KOVARIK J M,SCHMOUDER R,BARILLA D,et al.Multiple-dose FTY720:tolerability,pharmacokinetics,and lymphocyte responses in healthy subjects[J].Clinical Pharmacology,2004,44(5):532 -537.
  • 10KOVARIK J M,SCHMOUDER R,BARILLA D,et al.FTY720 and cyclosporine:evaluation for a pharmacokinetic interaction[Ann].Pharmacother,2004,38(7):1 153 -1 158.

二级参考文献15

  • 1Sun E W,J Med Coll PLA,1999年,14卷,103页
  • 2Wang M E,Trans plantation,1998年,65卷,899页
  • 3孙尔维,中华微生物学和免疫学杂志,1998年,18卷,377页
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  • 7Suzuki S,Li X-K,Shinomiya T,et al.The in vivo induction of lymphocyre apoptosis in MLR-1 pr/lpr mice treated with TY720[ J].Clin Exp Immunol,1997,107:103
  • 8Shinomiya T,Li X-K,Amemiya H,et al.An immunosuppressive agent FTY720 increases intracellular concentration of calciumion and induces apoptosis in HL-60[ J].Immunology,1997,91: 594
  • 9Suzuki S,Li X-K,Enosawa S,et al.A new immunosuppressant,FTY720,in human lymphocyte [J].Immunology,1996,89: 518
  • 10Matsyda S,Minowa A,Suzuki S,et al.Differential activation of c-Jun NH2-terminal and p38 pathways during FTY720-induced apoptosis of lymphocyte that is suppressed by the extranellular signal-regulated kinase pathway[J].J Immunol,1999,162: 3321

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