氟伐他汀治疗老年肾动脉粥样硬化性狭窄的疗效观察

Curative Effects of Fluvastian in Atherosclerotic Renal Artery Stenosis

目的探讨氟伐他汀对老年肾动脉粥样硬化所致肾动脉狭窄(ARAS)的治疗作用及其抗炎机制。方法54例老年ARAS患者,随机分为对照组和治疗组,对照组给予常规降压治疗,治疗组每晚加服氟伐他汀40mg。比较两组治疗前后尿蛋白排泄率(UAER)、血肌酐(Scr)、C反应蛋白(CRP)及肾脏血管多普勒超声肾动脉收缩期峰值速度(PSV)、肾动脉血流加速度时间(AT)、肾动脉峰值流速与肾动脉开口处腹主动脉流速之比(RAR)等指标。结果治疗组UAER及PSV、AT、RAR下降较对照组明显(P<0.05),治疗组CRP下降明显(P<0.05),对照组CRP变化不明显(P>0.05)。结论氟伐他汀因降低CRP促炎效应而改善肾动脉狭窄,且不依赖氟伐他汀的降血脂作用。

Objective To investigate the curative effects of fluvastain and its anti-inflammation mechanism in atherosclerotic renal artery stenosis （ARAS）. Methods 54 patients with ARAS were randomly divided into two groups ,the control group （ n = 27） and the treated group （ n = 27）. the control group received conventional therapy , while the treated group was added oral 40 microgram of fluvastatin every night . Compare the level of UAER, Scr and CRP 3,6 and 9months later respective, as well as PSV ,AT,RAR. Results factors such as UARE,Scr,PSV,AT and RAR had been decreased more significantly and quickly in treated group than in control group（ P 〈 0.05 ）, CRP had been decreased significantly in treated group（ P 〈 0.05 ） ,while no significantly decrease had been found in control group during the follow-up of nine months（P 〉 0.05）. Furthermore, similar results were also obtained in those ARAS with norm lipidemia when further analyzed. Conclusions fluvastain can meliorate microalbuminuria and inprove renal function by its antiinflammation effect by decreasing CRP, which is independent of its lowering lipidemia effect.