摘要
本研究对根除幽门螺杆菌(Hp)的三联疗法进行改良,减少其中阿莫西林及甲硝唑的剂量,对Hp阳性的173例慢性胃炎患者及267例十二指肠溃疡患者进行Hp根除治疗。用药方法为胶体次枸橼酸铋(德诺,CBS)120mg,阿莫西林250mg,及甲硝唑200mg同服,每日4次,连服14天,Hp根除率为86.8%。此外,对49例慢性胃炎及107例十二指肠溃疡Hp阳性者减少服药次数,采用每日2次给药,连服14天,Hp根除率89.1%。研究证明,低剂量三联疗法Hp根除率高,不良反应少,有较好的依从性。每日2次服药与每日4次服药临床疗效相似,Hp根除率差异无显著性(P>0.05)。
The aim of this open,comparative,randomized study was
to investigatethe efficacy and safety of amoxicillin 250mg+ metronidazole 200mg q.d.s.+
col-loidal bismuth subcitrate l20mg.s.or amoxicillin 500mg b.d.s.+metronidazole-400mg b.d.s.+
colloidal bismuth subcitrate 240mg b.d.s. for 2 weeks for eradication ofH.pylori. 596 patients
with .pyolri infection(222 patients with chronic gastritis and374 patients with duodenal ulcer
disease) were studied.H.pylori eradication rates were86.8%for the former regimen and 89.1%for
the latter(P>0.05).There were no majorside-effects noted in both regimens, not any difference in
symptom relief and ulcerhealing.This study showed both regimens were similarly effective and
well tolerated.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1996年第4期192-195,共4页
Chinese Journal of Digestion
关键词
幽门螺杆菌
药物疗法
阿莫西林
甲硝唑
Helicobacter pylori/drug therapy Colloidal bismuth
subcitrateAmoxicillin Metronidazole