低剂量三联疗法根除幽门螺杆菌的多中心临床研究

Helicobacter pylori eradication with low dose amoxicillin-metronidazole-colloi-dal bismtith subcitrate triple therapy : a nation-wide cooperative clinical studyin China

本研究对根除幽门螺杆菌（Ｈｐ）的三联疗法进行改良，减少其中阿莫西林及甲硝唑的剂量，对Ｈｐ阳性的１７３例慢性胃炎患者及２６７例十二指肠溃疡患者进行Ｈｐ根除治疗。用药方法为胶体次枸橼酸铋（德诺，ＣＢＳ）１２０ｍｇ，阿莫西林２５０ｍｇ，及甲硝唑２００ｍｇ同服，每日４次，连服１４天，Ｈｐ根除率为８６．８％。此外，对４９例慢性胃炎及１０７例十二指肠溃疡Ｈｐ阳性者减少服药次数，采用每日２次给药，连服１４天，Ｈｐ根除率８９．１％。研究证明，低剂量三联疗法Ｈｐ根除率高，不良反应少，有较好的依从性。每日２次服药与每日４次服药临床疗效相似，Ｈｐ根除率差异无显著性（Ｐ＞０．０５）。

The aim of this open,comparative,randomized study was to investigatethe efficacy and safety of amoxicillin 250mg+ metronidazole 200mg q.d.s.+ col-loidal bismuth subcitrate l20mg.s.or amoxicillin 500mg b.d.s.+metronidazole-400mg b.d.s.+ colloidal bismuth subcitrate 240mg b.d.s. for 2 weeks for eradication ofH.pylori. 596 patients with .pyolri infection(222 patients with chronic gastritis and374 patients with duodenal ulcer disease) were studied.H.pylori eradication rates were86.8%for the former regimen and 89.1%for the latter(P>0.05).There were no majorside-effects noted in both regimens, not any difference in symptom relief and ulcerhealing.This study showed both regimens were similarly effective and well tolerated.