初始多耐药结核68例临床分析

Clinic analysis on 68 cases of tuberculosis with primarily multidrug resistance

目的探讨初始多耐药结核的发病原因及治疗对策。方法回顾性分析我院1995年-2005年初治多耐药结核68例。结果68例患者全部为初治肺结核,初始耐药至少2种以上。所有患者均采用HKPO为基本治疗方案,在此基础上选用未用过或相对敏感的药物,并辅以中药及免疫支持治疗。结果经过以上治疗,痰菌阴转率61.76%。病情好转率89.70%。死亡率4.4%。结论初治多耐药患者治疗困难,应选择未用过或应用时间较短或较敏感的药物治疗,疗程相对较长,可选用中医中药和免疫调节剂辅助治疗。

Objective To investigate the emerged causes and treatment methods of primarily muhidrug resistant tuberculosis, Methods The data of 68 inpatients with primarily muhidrug resistant tuberculosis was retrospectively analyzed from 1995 to 2005. Results All of 68 cases were pulmonary tuberculosis of initial treatment, and the primarily resistant drugs were no less than 2 kind drugs, The treatment was based on the protocol of HKPO, and added other drug upon the data of drug sensitivity test, and assisted traditional Chinese medicine or immunomodulator. Through that treatment, the improvement rate of was 89.7%, and 61, 67% patients with positive sputum smear acid-fast converted into negative. The mortality of that tuberculosis was 4, 4%. Conclusion It is difficult for the treatment of primarily muhidrug resistant tuberculosis. It may be good chosen with the long time of HKPO therapy combined with other drug upon the data of drug sensitivity test, and assisted traditional Chinese medicine or immunomodulator.