大鼠扣带皮质一氧化氮合酶(NOS)阳性神经元的分布和脑缺血后的变化

Distribution and Ischemia-induced Changes of Nitric Oxide Synthase-positive Neurons in the Cingulate Areas in Rats

采用NADPH－d组织化学方法，观察了NOS阳性神经元在大鼠脑扣带皮质前部24区、32区、25区和后部23区、29区的分布，并夹闭双侧颈总动脉，造成脑缺血2h后，再观察各区NOS阳性神经元的变化。结果为扣带皮质前、后部的5个区均有NOS阳性神经元。其前部的24区NOS阳性神经元较多，后部的23区和29区次之，前部的32区和25区较少。夹闭双侧颈总动脉2h后，再观察的结果为扣带皮质前、后部NOS阳性神经元数量均明显增加（P＜0．01）。

Distribution of nitric oxide synthase (NOS)-positive neurons of cingulate areas and its changes following bilateral common carotid artery occlusion were investigated with nicotinamide adenosine dinucleotide phosphate diaphorase (NADPH-d) reaction. Positively stained NOS-neu-rons were observed in the areas 24, 32,and 25 of the anterior cingulate cortex,and in the areas 23 and 29 of the posterior cingulate cortex. After bilateral common carotid artery occlusion,the results showed that the NOS-positive neurons increased markedly in the areas 24, 32,25,23 and 29 of the cingulate cortex (P＜0.01)