肝病患者血清Ⅳ型胶原肽检测及临床评价

Clinical evaluation on detection of Type Ⅳ Collagen in serum of patients with liver disease

目的:探讨血清Ⅳ型胶原肽对肝纤维化的诊断价值。方法:采用ELISA法测定112例各种病毒性肝炎患者及50例健康献血者血清Ⅳ型胶原肽水平,比较各组病毒性肝炎之间及健康献血者血清Ⅳ型胶原水平差异,结合病理结果进行分析。结果:血清Ⅳ型胶原肽水平在慢性肝炎(中度)患者明显升高,以慢性肝炎(重度)、肝硬化者为最高,3组患者与其他组比较,差异有显著性(P<0.01),其升高程度与肝纤维化及肝病严重程度呈正相关。但与肝内炎症、坏死程度无明显关系。结论:动态测定血清Ⅳ型胶原肽水平,可作为反映慢性肝病肝纤维化严重程度和预后的指标。

Objective To research the diagnostic value of Type Ⅳ Collagen for hepatic fibrosis. Method ELISA was used to detect the level of Type Ⅳ Collagen in serum of 112 patients with virus hepatitis and 50 healthy people, and compared the different level of Type Ⅳ Collagen in serum. We analyzed the data combined with the pathological alteration. Results The level of Type Ⅳ Collagen in serum of patients with medium chronic hepatitis obviously heightened, and that of severe chronic hepatitis and hepatocirrhosis were the highest. Differences between these three groups and other groups were significant（P 〈0.01 ）. The increased degree was positively related to the degree of hepatic fibrosis and severity of liver disease, but the correlation with the degree of liver＇ s inflammation and necrosis wasn＇t obvious. Conclusion Detecting the level of Type Ⅳ Collagen in serum dynamicly can reflect the fibrosis degree of chronic liver disease and it＇s prognosis.